Tiotropium EP Impurity A

Name: Tiotropium EP Impurity A
Brand: Vaqora Chemicals
SKU: VQ-023901

About Tiotropium EP Impurity A

Tiotropium EP Impurity A (CAS 4746-63-8) is a pharmacopeial impurity of Tiotropium offered by Vaqora Chemicals. Formula C10H8O3S2, molecular weight 240.3 g/mol. The IUPAC name is 2-hydroxy-2,2-dithiophen-2-ylacetic acid. It is also known as Tiotropium Bromide - Impurity A or 2-Hydroxy-2,2-bis(2-thienyl) Acetic Acid.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Tiotropium to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer Tiotropium EP Impurity A in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Tiotropium

View every impurity, metabolite and intermediate we list for Tiotropium.

Tiotropium impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Tiotropium EP Impurity A
Catalogue No.	VQ-023901
CAS Number	4746-63-8
IUPAC name	2-hydroxy-2,2-dithiophen-2-ylacetic acid
Molecular formula	C₁₀H₈O₃S₂
Molecular weight	240.3 g/mol
Exact mass	239.9915
Grade	Reference Standard
HSN code	38229090
InChIKey	FVEJUHUCFCAYRP-UHFFFAOYSA-N
SMILES	C1=CSC(=C1)C(C2=CC=CS2)(C(=O)O)O
PubChem CID	12723754

Physical properties
Physical form	Solid
LogP (XLogP3)	1.7
H-bond donors / acceptors	2 / 5
TPSA	114 Å²
Synonyms	Tiotropium Bromide - Impurity A, 2-Hydroxy-2,2-bis(2-thienyl) Acetic Acid, Di-2-thienylglycolic acid, 2-Hydroxy-2,2-di(thiophen-2-yl)acetic acid, Glycolic acid, di-2-thienyl-, (Hydroxy)(di-2-thienyl)acetic acid, 2-hydroxy-2,2-bis(thiophen-2-yl)acetic acid, 2-hydroxy-2,2-di(2-thienyl)acetic acid, dithienylglycolic acid, Tiotropium Impurity A, alpha,alpha-Di(2-thienyl)glycolic acid, 2-Thiopheneacetic acid, alpha-hydroxy-alpha-2-thienyl-

Safety & hazard information (GHS)

Toxic

Signal word: Danger

Hazard statements

H331Toxic if inhaled

Precautionary statements: P261, P271, P304 + P340, P316, P321, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Tiotropium EP Impurity A?

The CAS Registry Number of Tiotropium EP Impurity A is 4746-63-8. It is also known as Tiotropium Bromide - Impurity A, 2-Hydroxy-2,2-bis(2-thienyl) Acetic Acid, Di-2-thienylglycolic acid.

What is the molecular formula and molecular weight of Tiotropium EP Impurity A?

Tiotropium EP Impurity A has the molecular formula C10H8O3S2 and a molecular weight of 240.3 g/mol. Its IUPAC name is 2-hydroxy-2,2-dithiophen-2-ylacetic acid.

What is Tiotropium EP Impurity A used for?

Tiotropium EP Impurity A is supplied as a characterised reference material related to Tiotropium. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Tiotropium EP Impurity A can I order?

We supply Tiotropium EP Impurity A in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Tiotropium EP Impurity A?

Yes. Every lot of Tiotropium EP Impurity A is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Tiotropium EP Impurity A be shipped internationally?

Yes. Tiotropium EP Impurity A is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.