Retrorsine

About Retrorsine

Retrorsine is a high-purity reference standard of Retrorsine carrying the CAS registry number 480-54-6. With the molecular formula C18H25NO6, it has a molar mass of 351.4 g/mol. Common synonyms include beta-Longilobine and cis-Retronecic acid ester of retronecine.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

As a reference sample of Retrorsine, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Retrorsine is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Retrorsine

View every impurity, metabolite and intermediate we list for Retrorsine.

Retrorsine impurities

Specifications & identifiers

Chemical identifiers
Product name	Retrorsine
Catalogue No.	VQ-033512
CAS Number	480-54-6
IUPAC name	(1R,4Z,6R,7S,17R)-4-ethylidene-7-hydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadec-11-ene-3,8-dione
Molecular formula	C₁₈H₂₅NO₆
Molecular weight	351.4 g/mol
Exact mass	351.1682
Grade	Reference Standard
HSN code	38229090
InChIKey	BCJMNZRQJAVDLD-CQRYIUNCSA-N
SMILES	C/C=C\1/C[C@H]([C@@](C(=O)OCC2=CCN3[C@H]2[C@@H](CC3)OC1=O)(CO)O)C
PubChem CID	5281743

Physical properties
Physical form	Solid
LogP (XLogP3)	0.6
H-bond donors / acceptors	2 / 7
TPSA	96.3 Å²
Synonyms	beta-Longilobine, cis-Retronecic acid ester of retronecine, 12,18-Dihydroxy-senecionan-11,16-dione, Senecionan-11,16-dione, 12,18-dihydroxy-, trans-15-Ethylidene-12beta-hydroxy-12alpha-hydroxymethyl-13beta-methylsenec-1-enine, 12,18-Dihydroxysenecionan-11,16-dione, Retrorsin, (15Z)-12,18-dihydroxysenecionan-11,16-dione, Retrorcine

Safety & hazard information (GHS)

Toxic

Signal word: Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements: P264, P270, P301 + P316, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Retrorsine?

The CAS Registry Number of Retrorsine is 480-54-6. It is also known as beta-Longilobine, cis-Retronecic acid ester of retronecine, 12,18-Dihydroxy-senecionan-11,16-dione.

What is the molecular formula and molecular weight of Retrorsine?

Retrorsine has the molecular formula C18H25NO6 and a molecular weight of 351.4 g/mol. Its IUPAC name is (1R,4Z,6R,7S,17R)-4-ethylidene-7-hydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadec-11-ene-3,8-dione.

What is Retrorsine used for?

Retrorsine is supplied as a characterised reference material related to Retrorsine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Retrorsine can I order?

We supply Retrorsine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Retrorsine?

Yes. Every lot of Retrorsine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Retrorsine be shipped internationally?

Yes. Retrorsine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.