6beta-Naltrexol

About 6beta-Naltrexol

6beta-Naltrexol is a metabolite or degradation product of Naltrexone carrying the CAS registry number 49625-89-0. Its molecular formula is C20H25NO4 and its molecular weight is 343.4 g/mol. Alternative names: 6β-Naltrexol and 6beta-Hydroxy Naltrexone.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Analytical teams use this compound to identify metabolites and degradants of Naltrexone, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Naltrexone

View every impurity, metabolite and intermediate we list for Naltrexone.

Naltrexone impurities

Specifications & identifiers

Chemical identifiers
Product name	6beta-Naltrexol
Catalogue No.	VQ-026829
CAS Number	49625-89-0
IUPAC name	(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol
Molecular formula	C₂₀H₂₅NO₄
Molecular weight	343.4 g/mol
Exact mass	343.1784
Grade	Reference Standard
HSN code	38229090
InChIKey	JLVNEHKORQFVQJ-PYIJOLGTSA-N
SMILES	C1C[C@]2([C@H]3CC4=C5[C@@]2(CCN3CC6CC6)[C@H]([C@@H]1O)OC5=C(C=C4)O)O
PubChem CID	5486554

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.4
H-bond donors / acceptors	3 / 5
TPSA	73.2 Å²
Synonyms	6β-Naltrexol, 6beta-Hydroxy Naltrexone, beta-Naltrexol, AIKO-150, 6beta-Hydroxynaltrexone, Morphinan-3,6,14-triol, 17-(cyclopropylmethyl)-4,5-epoxy-, (5.alpha.,6.beta.)-, 17-(Cyclopropylmethyl)-4,5-epoxymorphinan-3,6beta,14-triol, Morphinan-3,6,14-triol, 17-(cyclopropylmethyl)-4,5-epoxy-, (5alpha,6beta)-, 6alpha-Naltrexol, 6, A-Naltrexol, 6alpha-Hydroxynaltrexone

Safety & hazard information (GHS)

Environmental hazard

Signal word: Warning

Hazard statements

H400Very toxic to aquatic life

Precautionary statements: P273, P391, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 6beta-Naltrexol?

The CAS Registry Number of 6beta-Naltrexol is 49625-89-0. It is also known as 6β-Naltrexol, 6beta-Hydroxy Naltrexone, beta-Naltrexol.

What is the molecular formula and molecular weight of 6beta-Naltrexol?

6beta-Naltrexol has the molecular formula C20H25NO4 and a molecular weight of 343.4 g/mol. Its IUPAC name is (4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol.

What is 6beta-Naltrexol used for?

6beta-Naltrexol is supplied as a characterised reference material related to Naltrexone. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 6beta-Naltrexol can I order?

We supply 6beta-Naltrexol in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 6beta-Naltrexol?

Yes. Every lot of 6beta-Naltrexol is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 6beta-Naltrexol be shipped internationally?

Yes. 6beta-Naltrexol is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.