2-Hydroxyisocaproic acid

About 2-Hydroxyisocaproic acid

2-Hydroxyisocaproic acid is a metabolite or degradation product of Leucine carrying the CAS registry number 498-36-2. With the molecular formula C6H12O3, it has a molar mass of 132.16 g/mol. The IUPAC name is 2-hydroxy-4-methylpentanoic acid. It is also known as 2-Hydroxy-4-methylvaleric acid or Leucic acid.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 2 hazard statements. Review the Safety Data Sheet before use.

Analytical teams use this compound to identify metabolites and degradants of Leucine, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 2-Hydroxyisocaproic acid is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Leucine

View every impurity, metabolite and intermediate we list for Leucine.

Leucine impurities

Specifications & identifiers

Chemical identifiers
Product name	2-Hydroxyisocaproic acid
Catalogue No.	VQ-037835
CAS Number	498-36-2
IUPAC name	2-hydroxy-4-methylpentanoic acid
Molecular formula	C₆H₁₂O₃
Molecular weight	132.16 g/mol
Exact mass	132.0786
Grade	Reference Standard
HSN code	38229090
InChIKey	LVRFTAZAXQPQHI-UHFFFAOYSA-N
SMILES	CC(C)CC(C(=O)O)O
PubChem CID	92779

Physical properties
Physical form	Solid
LogP (XLogP3)	0.9
H-bond donors / acceptors	2 / 3
TPSA	57.5 Å²
Synonyms	2-Hydroxy-4-methylvaleric acid, Leucic acid, alpha-Hydroxyisocaproic acid, Pentanoic acid, 2-hydroxy-4-methyl-, DL-alpha-Hydroxyisocaproic acid, DL-leucic acid, leucinic acid, DL-2-Hydroxyisocaproic acid, alpha-Hydroxyisocaproate, DL-Leucate, DL-2-Hydroxy-4-methylvaleric acid

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation

Precautionary statements: P264, P264 + P265, P280, P302 + P352, P305 + P351 + P338, P321, P332 + P317, P337 + P317, P362 + P364

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2-Hydroxyisocaproic acid?

The CAS Registry Number of 2-Hydroxyisocaproic acid is 498-36-2. It is also known as 2-Hydroxy-4-methylvaleric acid, Leucic acid, alpha-Hydroxyisocaproic acid.

What is the molecular formula and molecular weight of 2-Hydroxyisocaproic acid?

2-Hydroxyisocaproic acid has the molecular formula C6H12O3 and a molecular weight of 132.16 g/mol. Its IUPAC name is 2-hydroxy-4-methylpentanoic acid.

What is 2-Hydroxyisocaproic acid used for?

2-Hydroxyisocaproic acid is supplied as a characterised reference material related to Leucine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2-Hydroxyisocaproic acid can I order?

We supply 2-Hydroxyisocaproic acid in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2-Hydroxyisocaproic acid?

Yes. Every lot of 2-Hydroxyisocaproic acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2-Hydroxyisocaproic acid be shipped internationally?

Yes. 2-Hydroxyisocaproic acid is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.