1 Chloro 2 isocyanato 4 trifluoromethyl benze… 50528-86-4

About 1 Chloro 2 isocyanato 4 trifluoromethyl benzene

1 Chloro 2 isocyanato 4 trifluoromethyl benzene is an impurity of Sorafenib carrying the CAS registry number 50528-86-4. Formula C8H3ClF3NO, molecular weight 221.56 g/mol. Alternative names: 2-Chloro-5-(trifluoromethyl)phenyl isocyanate and 2-chloro-5-trifluoromethylphenyl isocyanate.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

This Sorafenib impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Sorafenib

View every impurity, metabolite and intermediate we list for Sorafenib.

Sorafenib impurities

Specifications & identifiers

Chemical identifiers
Product name	1 Chloro 2 isocyanato 4 trifluoromethyl benzene
Catalogue No.	VQ-042238
CAS Number	50528-86-4
IUPAC name	1-chloro-2-isocyanato-4-(trifluoromethyl)benzene
Molecular formula	C₈H₃ClF₃NO
Molecular weight	221.56 g/mol
Exact mass	220.9855
Grade	Reference Standard
HSN code	38229090
InChIKey	WEPYOPYMWSHRIW-UHFFFAOYSA-N
SMILES	C1=CC(=C(C=C1C(F)(F)F)N=C=O)Cl
PubChem CID	2733263

Physical properties
Physical form	Solid
LogP (XLogP3)	4.2
H-bond donors / acceptors	0 / 5
TPSA	29.4 Å²
Synonyms	2-Chloro-5-(trifluoromethyl)phenyl isocyanate, Isocyanic Acid 2-Chloro-5-(trifluoromethyl)phenyl Ester, 2-chloro-5-trifluoromethylphenyl isocyanate, 2-chloro-5-(trifluoromethyl)benzenisocyanate, 2-Chloro-5-(trifluoromethyl)phenylisocyanate, 1-chloro-2-iso, Benzene, 1-chloro-2-isocyanato-4-(trifluoromethyl)-, 2-chloro-5-trifluoromethylphenylisocyanate, 2-chloro-5-trifluoromethyl-phenyl isocyanate, 5-Trifluoro methyl-2-chloro phenyl isocyanate

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H332Harmful if inhaled
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation

Precautionary statements: P233, P260, P261, P264, P264 + P265, P270, P271, P280, P284, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P316, P317, P319, P321, P330, P332 + P317, P337 + P317, P342 + P316, P362 + P364, P403, P403 + P233

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 1 Chloro 2 isocyanato 4 trifluoromethyl benzene?

The CAS Registry Number of 1 Chloro 2 isocyanato 4 trifluoromethyl benzene is 50528-86-4. It is also known as 2-Chloro-5-(trifluoromethyl)phenyl isocyanate, Isocyanic Acid 2-Chloro-5-(trifluoromethyl)phenyl Ester, 2-chloro-5-trifluoromethylphenyl isocyanate.

What is the molecular formula and molecular weight of 1 Chloro 2 isocyanato 4 trifluoromethyl benzene?

1 Chloro 2 isocyanato 4 trifluoromethyl benzene has the molecular formula C8H3ClF3NO and a molecular weight of 221.56 g/mol. Its IUPAC name is 1-chloro-2-isocyanato-4-(trifluoromethyl)benzene.

What is 1 Chloro 2 isocyanato 4 trifluoromethyl benzene used for?

1 Chloro 2 isocyanato 4 trifluoromethyl benzene is supplied as a characterised reference material related to Sorafenib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 1 Chloro 2 isocyanato 4 trifluoromethyl benzene can I order?

We supply 1 Chloro 2 isocyanato 4 trifluoromethyl benzene in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 1 Chloro 2 isocyanato 4 trifluoromethyl benzene?

Yes. Every lot of 1 Chloro 2 isocyanato 4 trifluoromethyl benzene is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 1 Chloro 2 isocyanato 4 trifluoromethyl benzene be shipped internationally?

Yes. 1 Chloro 2 isocyanato 4 trifluoromethyl benzene is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.