O-Desmethyl Quinine

About O-Desmethyl Quinine

O-Desmethyl Quinine is a metabolite or degradation product of Quinine carrying the CAS registry number 524-63-0. Its molecular formula is C19H22N2O2 and its molecular weight is 310.4 g/mol. The IUPAC name is 4-[(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-hydroxymethyl]quinolin-6-ol. Common synonyms include Cupreine and 6'-Hydroxycinchonidine.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 4 hazard statements. Review the Safety Data Sheet before use.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Quinine, as well as in QC testing and ANDA/DMF documentation. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer O-Desmethyl Quinine in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Quinine

View every impurity, metabolite and intermediate we list for Quinine.

Quinine impurities

Specifications & identifiers

Chemical identifiers
Product name	O-Desmethyl Quinine
Catalogue No.	VQ-041807
CAS Number	524-63-0
IUPAC name	4-[(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-hydroxymethyl]quinolin-6-ol
Molecular formula	C₁₉H₂₂N₂O₂
Molecular weight	310.4 g/mol
Exact mass	310.1681
Grade	Reference Standard
HSN code	38229090
InChIKey	VJFMSYZSFUWQPZ-BIPCEHGGSA-N
SMILES	C=C[C@H]1CN2CC[C@H]1C[C@H]2[C@@H](C3=C4C=C(C=CC4=NC=C3)O)O
PubChem CID	92792

Physical properties
Physical form	Solid
LogP (XLogP3)	2.6
H-bond donors / acceptors	2 / 4
TPSA	56.6 Å²
Synonyms	Cupreine, 6'-Hydroxycinchonidine, (8alpha,9R)-Cinchonan-6',9-diol, O-Demethylquinidien, 4-((R)-((2R,4S,5R)-5-ethenyl-1-azabicyclo(2.2.2)octan-2-yl)-hydroxymethyl)quinolin-6-ol, 4-((R)-((2S,4S,5R)-5-ethenyl-1-azabicyclo(2.2.2)octan-2-yl)-hydroxymethyl)quinolin-6-ol, (9R)-cinchonan-6',9-diol, 4-((R)-Hydroxy((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)quinolin-6-ol, ultraquinine, (8,9R)-Cinchonan-6',9-diol, Cuprein, (8,9R)-9-Diol cinchonan-6'

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation

Precautionary statements: P261, P264, P264 + P265, P270, P272, P280, P301 + P317, P302 + P352, P305 + P351 + P338, P321, P330, P332 + P317, P333 + P317, P337 + P317, P362 + P364, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of O-Desmethyl Quinine?

The CAS Registry Number of O-Desmethyl Quinine is 524-63-0. It is also known as Cupreine, 6'-Hydroxycinchonidine, (8alpha,9R)-Cinchonan-6',9-diol.

What is the molecular formula and molecular weight of O-Desmethyl Quinine?

O-Desmethyl Quinine has the molecular formula C19H22N2O2 and a molecular weight of 310.4 g/mol. Its IUPAC name is 4-[(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-hydroxymethyl]quinolin-6-ol.

What is O-Desmethyl Quinine used for?

O-Desmethyl Quinine is supplied as a characterised reference material related to Quinine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of O-Desmethyl Quinine can I order?

We supply O-Desmethyl Quinine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with O-Desmethyl Quinine?

Yes. Every lot of O-Desmethyl Quinine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can O-Desmethyl Quinine be shipped internationally?

Yes. O-Desmethyl Quinine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.