(5a)-Pregnane-3,20-dione

Name: (5a)-Pregnane-3,20-dione
Brand: Vaqora Chemicals
SKU: VQ-033162

About (5a)-Pregnane-3,20-dione

Listed under CAS 566-65-4, (5a)-Pregnane-3,20-dione is an impurity of Progesterone available from Vaqora Chemicals. With the molecular formula C21H32O2, it has a molar mass of 316.5 g/mol. It is also known as 5alpha-Pregnane-3,20-dione or 3,20-Allopregnanedione.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Pharmaceutical QC and development laboratories use this impurity standard of Progesterone to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies (5a)-Pregnane-3,20-dione in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Progesterone

View every impurity, metabolite and intermediate we list for Progesterone.

Progesterone impurities

Specifications & identifiers

Chemical identifiers
Product name	(5a)-Pregnane-3,20-dione
Catalogue No.	VQ-033162
CAS Number	566-65-4
IUPAC name	(5S,8R,9S,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
Molecular formula	C₂₁H₃₂O₂
Molecular weight	316.5 g/mol
Exact mass	316.2402
Grade	Reference Standard
HSN code	38229090
InChIKey	XMRPGKVKISIQBV-BJMCWZGWSA-N
SMILES	CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CCC(=O)C4)C)C
PubChem CID	92810

Physical properties
Physical form	Solid
LogP (XLogP3)	4.4
H-bond donors / acceptors	0 / 2
TPSA	34.1 Å²
Synonyms	5alpha-Pregnane-3,20-dione, 3,20-Allopregnanedione, 5-alpha-Dihydroprogesterone, 5alpha-Dihydroprogesterone, 3,20-Dioxo-5alpha-pregnane, 5alpha DHP, 5alpha-DHP, 5beta DHP, 5beta-DHP, 5-alpha-Pregnanedione

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
H351Suspected of causing cancer
H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P261, P264, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P317, P318, P321, P330, P362 + P364, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (5a)-Pregnane-3,20-dione?

The CAS Registry Number of (5a)-Pregnane-3,20-dione is 566-65-4. It is also known as 5alpha-Pregnane-3,20-dione, 3,20-Allopregnanedione, 5-alpha-Dihydroprogesterone.

What is the molecular formula and molecular weight of (5a)-Pregnane-3,20-dione?

(5a)-Pregnane-3,20-dione has the molecular formula C21H32O2 and a molecular weight of 316.5 g/mol. Its IUPAC name is (5S,8R,9S,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one.

What is (5a)-Pregnane-3,20-dione used for?

(5a)-Pregnane-3,20-dione is supplied as a characterised reference material related to Progesterone. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (5a)-Pregnane-3,20-dione can I order?

We supply (5a)-Pregnane-3,20-dione in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (5a)-Pregnane-3,20-dione?

Yes. Every lot of (5a)-Pregnane-3,20-dione is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (5a)-Pregnane-3,20-dione be shipped internationally?

Yes. (5a)-Pregnane-3,20-dione is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.