Megestrol acetate

About Megestrol acetate

Megestrol acetate is a high-purity reference standard of Megestrol carrying the CAS registry number 595-33-5. With the molecular formula C24H32O4, it has a molar mass of 384.5 g/mol. Common synonyms include Megestryl acetate and Niagestin.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Danger” with 9 hazard statements. Review the Safety Data Sheet before use.

As a reference sample of Megestrol, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Megestrol acetate is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Megestrol

View every impurity, metabolite and intermediate we list for Megestrol.

Megestrol impurities

Specifications & identifiers

Chemical identifiers
Product name	Megestrol acetate
Catalogue No.	VQ-021271
CAS Number	595-33-5
IUPAC name	[(8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
Molecular formula	C₂₄H₃₂O₄
Molecular weight	384.5 g/mol
Exact mass	384.2301
Grade	Reference Standard
HSN code	38229090
InChIKey	RQZAXGRLVPAYTJ-GQFGMJRRSA-N
SMILES	CC1=C[C@@H]2[C@H](CC[C@]3([C@H]2CC[C@@]3(C(=O)C)OC(=O)C)C)[C@@]4(C1=CC(=O)CC4)C
PubChem CID	11683

Physical properties
Physical form	Solid
LogP (XLogP3)	3.1
H-bond donors / acceptors	0 / 4
TPSA	60.4 Å²
Synonyms	Megestryl acetate, Niagestin, Megace ES, BDH 1298, Magestin, Megesterol acetate, BDH-1298, 17alpha-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate, 17alpha-Acetoxy-6-dehydro-6-methylprogesterone, 6-Dehydro-6-methyl-17alpha-acetoxyprogesterone, 6-Methyl-6-dehydro-17alpha-acetoxyprogesterone, 17-Acetoxy-6-methylpregna-4,6-diene-3,20-dione

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
H341Suspected of causing genetic defects
H350May cause cancer
H351Suspected of causing cancer
H360May damage fertility or the unborn child
H362May cause harm to breast-fed children
H373May causes damage to organs through prolonged or repeated exposure

Precautionary statements: P203, P260, P261, P263, P264, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P317, P318, P319, P321, P330, P362 + P364, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Megestrol acetate?

The CAS Registry Number of Megestrol acetate is 595-33-5. It is also known as Megestryl acetate, Niagestin, Megace ES.

What is the molecular formula and molecular weight of Megestrol acetate?

Megestrol acetate has the molecular formula C24H32O4 and a molecular weight of 384.5 g/mol. Its IUPAC name is [(8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate.

What is Megestrol acetate used for?

Megestrol acetate is supplied as a characterised reference material related to Megestrol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Megestrol acetate can I order?

We supply Megestrol acetate in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Megestrol acetate?

Yes. Every lot of Megestrol acetate is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Megestrol acetate be shipped internationally?

Yes. Megestrol acetate is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.