4-Hydroxy-3,5-diiodobenzoic Acid

Name: 4-Hydroxy-3,5-diiodobenzoic Acid
Brand: Vaqora Chemicals
SKU: VQ-049785

About 4-Hydroxy-3,5-diiodobenzoic Acid

4-Hydroxy-3,5-diiodobenzoic Acid (CAS 618-76-8) is a metabolite or degradation product of Levothyroxine offered by Vaqora Chemicals. Its molecular formula is C7H4I2O3 and its molecular weight is 389.91 g/mol. It is also known as 3,5-Diiodo-4-hydroxybenzoic Acid or Ioxynic acid.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Analytical teams use this compound to identify metabolites and degradants of Levothyroxine, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies 4-Hydroxy-3,5-diiodobenzoic Acid in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Levothyroxine

View every impurity, metabolite and intermediate we list for Levothyroxine.

Levothyroxine impurities

Specifications & identifiers

Chemical identifiers
Product name	4-Hydroxy-3,5-diiodobenzoic Acid
Catalogue No.	VQ-049785
CAS Number	618-76-8
IUPAC name	4-hydroxy-3,5-diiodobenzoic acid
Molecular formula	C₇H₄I₂O₃
Molecular weight	389.91 g/mol
Exact mass	389.825
Grade	Reference Standard
HSN code	38229090
InChIKey	XREKTVACBXQCSB-UHFFFAOYSA-N
SMILES	C1=C(C=C(C(=C1I)O)I)C(=O)O
PubChem CID	12065

Physical properties
Physical form	Solid
LogP (XLogP3)	1.8
H-bond donors / acceptors	2 / 3
TPSA	57.5 Å²
Synonyms	3,5-Diiodo-4-hydroxybenzoic Acid, Ioxynic acid, Ioxynil acid, Benzoic acid, 4-hydroxy-3,5-diiodo-, Ioxynil metabolite, 3,5-di-iodo-4-hydroxybenzoic acid, 3,5-Diiodo-4-hydroxy-benzoic acid

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4-Hydroxy-3,5-diiodobenzoic Acid?

The CAS Registry Number of 4-Hydroxy-3,5-diiodobenzoic Acid is 618-76-8. It is also known as 3,5-Diiodo-4-hydroxybenzoic Acid, Ioxynic acid, Ioxynil acid.

What is the molecular formula and molecular weight of 4-Hydroxy-3,5-diiodobenzoic Acid?

4-Hydroxy-3,5-diiodobenzoic Acid has the molecular formula C7H4I2O3 and a molecular weight of 389.91 g/mol. Its IUPAC name is 4-hydroxy-3,5-diiodobenzoic acid.

What is 4-Hydroxy-3,5-diiodobenzoic Acid used for?

4-Hydroxy-3,5-diiodobenzoic Acid is supplied as a characterised reference material related to Levothyroxine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4-Hydroxy-3,5-diiodobenzoic Acid can I order?

We supply 4-Hydroxy-3,5-diiodobenzoic Acid in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4-Hydroxy-3,5-diiodobenzoic Acid?

Yes. Every lot of 4-Hydroxy-3,5-diiodobenzoic Acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4-Hydroxy-3,5-diiodobenzoic Acid be shipped internationally?

Yes. 4-Hydroxy-3,5-diiodobenzoic Acid is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.