3-Amino-2-chlorobenzotrifluoride

About 3-Amino-2-chlorobenzotrifluoride

3-Amino-2-chlorobenzotrifluoride is a process intermediate or related compound of Regorafenib carrying the CAS registry number 62476-58-8. Formula C7H5ClF3N, molecular weight 195.57 g/mol. Systematically, it is named 2-chloro-3-(trifluoromethyl)aniline. It is also known as 2-chloro-3-(trifluoromethyl)benzenamine or (2-Chloro-3-trifluoromethylphenyl)amine.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

Process chemists and analysts use it when developing synthetic routes to Regorafenib, tracking process-related impurities and validating analytical methods. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development
Fine chemical synthesis

Industries

Related to Regorafenib

View every impurity, metabolite and intermediate we list for Regorafenib.

Regorafenib impurities

Specifications & identifiers

Chemical identifiers
Product name	3-Amino-2-chlorobenzotrifluoride
Catalogue No.	VQ-039269
CAS Number	62476-58-8
IUPAC name	2-chloro-3-(trifluoromethyl)aniline
Molecular formula	C₇H₅ClF₃N
Molecular weight	195.57 g/mol
Exact mass	195.0063
HSN code	2933
InChIKey	WLXOMMTWPMQFDE-UHFFFAOYSA-N
SMILES	C1=CC(=C(C(=C1)N)Cl)C(F)(F)F
PubChem CID	4984136

Physical properties
Physical form	Solid
LogP (XLogP3)	2.8
H-bond donors / acceptors	1 / 4
TPSA	26 Å²
Synonyms	2-chloro-3-(trifluoromethyl)benzenamine, (2-Chloro-3-trifluoromethylphenyl)amine, Benzenamine, 2-chloro-3-(trifluoromethyl)-, 2-chloro-3-trifluoromethyl-phenylamine, 2-chloro-3-(trifluoromethyl)phenylamine

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H311Toxic in contact with skin
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation

Precautionary statements: P261, P262, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P316, P317, P319, P321, P330, P332 + P317, P337 + P317, P361 + P364, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 3-Amino-2-chlorobenzotrifluoride?

The CAS Registry Number of 3-Amino-2-chlorobenzotrifluoride is 62476-58-8. It is also known as 2-chloro-3-(trifluoromethyl)benzenamine, (2-Chloro-3-trifluoromethylphenyl)amine, Benzenamine, 2-chloro-3-(trifluoromethyl)-.

What is the molecular formula and molecular weight of 3-Amino-2-chlorobenzotrifluoride?

3-Amino-2-chlorobenzotrifluoride has the molecular formula C7H5ClF3N and a molecular weight of 195.57 g/mol. Its IUPAC name is 2-chloro-3-(trifluoromethyl)aniline.

What is 3-Amino-2-chlorobenzotrifluoride used for?

3-Amino-2-chlorobenzotrifluoride is supplied as a characterised reference material related to Regorafenib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 3-Amino-2-chlorobenzotrifluoride can I order?

We supply 3-Amino-2-chlorobenzotrifluoride, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 3-Amino-2-chlorobenzotrifluoride?

Yes. Every lot of 3-Amino-2-chlorobenzotrifluoride is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 3-Amino-2-chlorobenzotrifluoride be shipped internationally?

Yes. 3-Amino-2-chlorobenzotrifluoride is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.