Brivanib

About Brivanib

Brivanib is a high-purity reference standard of Brivanib carrying the CAS registry number 649735-46-6. Formula C19H19FN4O3, molecular weight 370.4 g/mol. The IUPAC name is (2R)-1-[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxypropan-2-ol. It is also known as Brivanib (USAN) or EX-A011.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

As a reference sample of Brivanib, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Brivanib

View every impurity, metabolite and intermediate we list for Brivanib.

Brivanib impurities

Specifications & identifiers

Chemical identifiers
Product name	Brivanib
Catalogue No.	VQ-043077
CAS Number	649735-46-6
IUPAC name	(2R)-1-[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxypropan-2-ol
Molecular formula	C₁₉H₁₉FN₄O₃
Molecular weight	370.4 g/mol
Exact mass	370.1441
Grade	Reference Standard
HSN code	38229090
InChIKey	WCWUXEGQKLTGDX-LLVKDONJSA-N
SMILES	CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NN4C3=C(C(=C4)OC[C@@H](C)O)C
PubChem CID	11234052

Physical properties
Physical form	Solid
LogP (XLogP3)	3
H-bond donors / acceptors	2 / 6
TPSA	84.7 Å²

Safety & hazard information (GHS)

Health hazard

Signal word: Danger

Hazard statements

H360May damage fertility or the unborn child
H361Suspected of damaging fertility or the unborn child
H373May causes damage to organs through prolonged or repeated exposure

Precautionary statements: P203, P260, P280, P318, P319, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Brivanib?

The CAS Registry Number of Brivanib is 649735-46-6. It is also known as Brivanib (USAN), EX-A011, CPD 12.

What is the molecular formula and molecular weight of Brivanib?

Brivanib has the molecular formula C19H19FN4O3 and a molecular weight of 370.4 g/mol. Its IUPAC name is (2R)-1-[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxypropan-2-ol.

What is Brivanib used for?

Brivanib is supplied as a characterised reference material related to Brivanib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Brivanib can I order?

We supply Brivanib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Brivanib?

Yes. Every lot of Brivanib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Brivanib be shipped internationally?

Yes. Brivanib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.