4-Chloro-N-nitrosopiperidine

Name: 4-Chloro-N-nitrosopiperidine
Brand: Vaqora Chemicals
SKU: VQ-027255

About 4-Chloro-N-nitrosopiperidine

Vaqora Chemicals supplies 4-Chloro-N-nitrosopiperidine, a nitrosamine impurity of Ketotifen registered under CAS number 65445-61-6. Formula C5H9ClN2O, molecular weight 148.59 g/mol. Its systematic (IUPAC) name is 4-chloro-1-nitrosopiperidine. Common synonyms include N-nitroso-4-chloropiperidine and 4-Chloronitrosopiperidine.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Laboratories use this nitrosamine standard to develop and validate highly sensitive LC-MS/MS methods, to confirm limits of detection and to document nitrosamine risk assessments in regulatory submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 4-Chloro-N-nitrosopiperidine is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Ketotifen

View every impurity, metabolite and intermediate we list for Ketotifen.

Ketotifen impurities

Specifications & identifiers

Chemical identifiers
Product name	4-Chloro-N-nitrosopiperidine
Catalogue No.	VQ-027255
CAS Number	65445-61-6
IUPAC name	4-chloro-1-nitrosopiperidine
Molecular formula	C₅H₉ClN₂O
Molecular weight	148.59 g/mol
Exact mass	148.0403
Grade	Reference Standard
HSN code	38229090
InChIKey	NSWBTWAHSWWHDN-UHFFFAOYSA-N
SMILES	C1CN(CCC1Cl)N=O
PubChem CID	127854

Physical properties
Physical form	Solid
LogP (XLogP3)	0.4
H-bond donors / acceptors	0 / 3
TPSA	32.7 Å²
Synonyms	N-nitroso-4-chloropiperidine, 4-Chloronitrosopiperidine, Piperidine,4-chloro-1-nitroso-, Piperidine, 4-chloro-1-nitroso-, 4-chloro-nitrosopiperidine, 4-Chloro-1-nitroso-piperidine

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H340May cause genetic defects
H350May cause cancer

Precautionary statements: P203, P261, P264, P264 + P265, P270, P271, P280, P301 + P316, P302 + P352, P304 + P340, P305 + P351 + P338, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4-Chloro-N-nitrosopiperidine?

The CAS Registry Number of 4-Chloro-N-nitrosopiperidine is 65445-61-6. It is also known as N-nitroso-4-chloropiperidine, 4-Chloronitrosopiperidine, Piperidine,4-chloro-1-nitroso-.

What is the molecular formula and molecular weight of 4-Chloro-N-nitrosopiperidine?

4-Chloro-N-nitrosopiperidine has the molecular formula C5H9ClN2O and a molecular weight of 148.59 g/mol. Its IUPAC name is 4-chloro-1-nitrosopiperidine.

What is 4-Chloro-N-nitrosopiperidine used for?

4-Chloro-N-nitrosopiperidine is supplied as a characterised reference material related to Ketotifen. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4-Chloro-N-nitrosopiperidine can I order?

We supply 4-Chloro-N-nitrosopiperidine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4-Chloro-N-nitrosopiperidine?

Yes. Every lot of 4-Chloro-N-nitrosopiperidine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4-Chloro-N-nitrosopiperidine be shipped internationally?

Yes. 4-Chloro-N-nitrosopiperidine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.