Etoposide EP Impurity E

About Etoposide EP Impurity E

Etoposide EP Impurity E is a pharmacopeial impurity of Etoposide carrying the CAS registry number 6559-91-7. Formula C21H20O8, molecular weight 400.4 g/mol. Alternative names: 4-Demethylepipodophyllotoxin and Etoposide - Impurity E.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Danger” with 5 hazard statements. Review the Safety Data Sheet before use.

As a characterised impurity of Etoposide, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer Etoposide EP Impurity E in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Etoposide

View every impurity, metabolite and intermediate we list for Etoposide.

Etoposide impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Etoposide EP Impurity E
Catalogue No.	VQ-022605
CAS Number	6559-91-7
IUPAC name	(5S,5aR,8aR,9R)-5-hydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one
Molecular formula	C₂₁H₂₀O₈
Molecular weight	400.4 g/mol
Exact mass	400.1158
Grade	Reference Standard
HSN code	38229090
InChIKey	YVCVYCSAAZQOJI-JHQYFNNDSA-N
SMILES	COC1=CC(=CC(=C1O)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](C4=CC5=C(C=C24)OCO5)O
PubChem CID	122797

Physical properties
Physical form	Solid
LogP (XLogP3)	1.7
H-bond donors / acceptors	2 / 8
TPSA	104 Å²
Synonyms	4-Demethylepipodophyllotoxin, Etoposide - Impurity E, Podophyllotoxin - Impurity B, 4'-Demethylepipodophyllotoxin, (-)-4'-Demethylepipodophyllotoxin, 4'-O-demethylepipodophyllotoxin, 4'-demethyl epipodophyllotoxin, 4'-DMEP, 4'-demethyl-9-epipodophyllotoxin, 4-Domethylpodophyllotoxin, 4'-demethyl-epi-podophyllotoxin, etoposide aglycone, epi-4'-demethylpodophyllotoxin

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H340May cause genetic defects
H350May cause cancer
H360May damage fertility or the unborn child

Precautionary statements: P203, P264, P264 + P265, P280, P302 + P352, P305 + P351 + P338, P318, P321, P332 + P317, P337 + P317, P362 + P364, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Etoposide EP Impurity E?

The CAS Registry Number of Etoposide EP Impurity E is 6559-91-7. It is also known as 4-Demethylepipodophyllotoxin, Etoposide - Impurity E, Podophyllotoxin - Impurity B.

What is the molecular formula and molecular weight of Etoposide EP Impurity E?

Etoposide EP Impurity E has the molecular formula C21H20O8 and a molecular weight of 400.4 g/mol. Its IUPAC name is (5S,5aR,8aR,9R)-5-hydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one.

What is Etoposide EP Impurity E used for?

Etoposide EP Impurity E is supplied as a characterised reference material related to Etoposide. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Etoposide EP Impurity E can I order?

We supply Etoposide EP Impurity E in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Etoposide EP Impurity E?

Yes. Every lot of Etoposide EP Impurity E is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Etoposide EP Impurity E be shipped internationally?

Yes. Etoposide EP Impurity E is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.