N-Desmethyl Loperamide

Name: N-Desmethyl Loperamide
Brand: Vaqora Chemicals
SKU: VQ-023000

About N-Desmethyl Loperamide

Listed under CAS 66164-07-6, N-Desmethyl Loperamide is a metabolite or degradation product of Loperamide available from Vaqora Chemicals. Formula C28H31ClN2O2, molecular weight 463.0 g/mol. Systematically, it is named 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N-methyl-2,2-diphenylbutanamide. Common synonyms include Desmethyl Loperamide and Loperamide metabolite M3.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Good laboratory practice and suitable PPE are recommended during handling.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Loperamide, as well as in QC testing and ANDA/DMF documentation. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Loperamide

View every impurity, metabolite and intermediate we list for Loperamide.

Loperamide impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Desmethyl Loperamide
Catalogue No.	VQ-023000
CAS Number	66164-07-6
IUPAC name	4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N-methyl-2,2-diphenylbutanamide
Molecular formula	C₂₈H₃₁ClN₂O₂
Molecular weight	463 g/mol
Exact mass	462.2074
Grade	Reference Standard
HSN code	38229090
InChIKey	ZMOPTLXEYOVARP-UHFFFAOYSA-N
SMILES	CNC(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4
PubChem CID	9805944

Physical properties
Physical form	Solid
LogP (XLogP3)	4.8
H-bond donors / acceptors	2 / 3
TPSA	52.6 Å²
Synonyms	Desmethyl Loperamide, Loperamide metabolite M3, N-demethyl-loperamide, monodesmethyl loperamide, (11C)N-desmethyl-loperamide, 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-methyl-2,2-diphenylbutanamide, 4-(4-Chlorophenyl)-4-hydroxy-N-methyl-alpha,alpha-diphenyl-1-piperidinebutanamide, (N-methyl-11C)-desmethyl-loperamide, N-Demethylloperamide

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Desmethyl Loperamide?

The CAS Registry Number of N-Desmethyl Loperamide is 66164-07-6. It is also known as Desmethyl Loperamide, Loperamide metabolite M3, N-demethyl-loperamide.

What is the molecular formula and molecular weight of N-Desmethyl Loperamide?

N-Desmethyl Loperamide has the molecular formula C28H31ClN2O2 and a molecular weight of 463 g/mol. Its IUPAC name is 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N-methyl-2,2-diphenylbutanamide.

What is N-Desmethyl Loperamide used for?

N-Desmethyl Loperamide is supplied as a characterised reference material related to Loperamide. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Desmethyl Loperamide can I order?

We supply N-Desmethyl Loperamide in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Desmethyl Loperamide?

Yes. Every lot of N-Desmethyl Loperamide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Desmethyl Loperamide be shipped internationally?

Yes. We export N-Desmethyl Loperamide worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.