Glipizide EP Impurity E

About Glipizide EP Impurity E

Glipizide EP Impurity E is a pharmacopeial impurity of Glipizide carrying the CAS registry number 66375-96-0. Its molecular formula is C21H27N5O4S and its molecular weight is 445.5 g/mol. Its systematic (IUPAC) name is N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-6-methylpyrazine-2-carboxamide. Common synonyms include Glipizide - Impurity E and 5-Desmethyl-6-methyl Glipizide.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

This Glipizide impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Glipizide

View every impurity, metabolite and intermediate we list for Glipizide.

Glipizide impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Glipizide EP Impurity E
Catalogue No.	VQ-026002
CAS Number	66375-96-0
IUPAC name	N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-6-methylpyrazine-2-carboxamide
Molecular formula	C₂₁H₂₇N₅O₄S
Molecular weight	445.5 g/mol
Exact mass	445.1784
Grade	Reference Standard
HSN code	38229090
InChIKey	UARTXGOLEHZWRF-UHFFFAOYSA-N
SMILES	CC1=CN=CC(=N1)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3
PubChem CID	71315772

Physical properties
Physical form	Solid
LogP (XLogP3)	1.9
H-bond donors / acceptors	3 / 6
TPSA	139 Å²
Synonyms	Glipizide - Impurity E, 1-Cyclohexyl-3-((4-(2-(((6-methylpyrazin-2-yl)carbonyl)amino)ethyl)phenyl)sulfonyl)urea, 1-Cyclohexyl-3-{{4-{2-{[(6-methylpyrazin-2-yl)carbonyl]amino}ethyl}phenyl}sulfonyl}urea, 5-Desmethyl-6-methyl Glipizide, 1-Cyclohexyl-3-[[4-[2-[[(6-methylpyrazin-2-yl)carbonyl]amino]ethyl]phenyl] sulphonyl]urea, 1-Cyclohexyl-3-[[4-[2-[[(6-methylpyrazin-2-yl)carbonyl]amino]ethyl]phenyl]sulphonyl]urea, N-(2-{4-[(Cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-6-methylpyrazine-2-carboxamide

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements: P264, P270, P301 + P317, P330, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Glipizide EP Impurity E?

The CAS Registry Number of Glipizide EP Impurity E is 66375-96-0. It is also known as Glipizide - Impurity E, 1-Cyclohexyl-3-((4-(2-(((6-methylpyrazin-2-yl)carbonyl)amino)ethyl)phenyl)sulfonyl)urea, 1-Cyclohexyl-3-{{4-{2-{[(6-methylpyrazin-2-yl)carbonyl]amino}ethyl}phenyl}sulfonyl}urea.

What is the molecular formula and molecular weight of Glipizide EP Impurity E?

Glipizide EP Impurity E has the molecular formula C21H27N5O4S and a molecular weight of 445.5 g/mol. Its IUPAC name is N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-6-methylpyrazine-2-carboxamide.

What is Glipizide EP Impurity E used for?

Glipizide EP Impurity E is supplied as a characterised reference material related to Glipizide. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Glipizide EP Impurity E can I order?

We supply Glipizide EP Impurity E in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Glipizide EP Impurity E?

Yes. Every lot of Glipizide EP Impurity E is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Glipizide EP Impurity E be shipped internationally?

Yes. Glipizide EP Impurity E is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.