1-(1,4-Benzodioxan-2-ylcarbonyl)piperazine

Name: 1-(1,4-Benzodioxan-2-ylcarbonyl)piperazine
Brand: Vaqora Chemicals
SKU: VQ-048087

About 1-(1,4-Benzodioxan-2-ylcarbonyl)piperazine

1-(1,4-Benzodioxan-2-ylcarbonyl)piperazine (CAS 70918-00-2) is an impurity of Doxazosin offered by Vaqora Chemicals. With the molecular formula C13H16N2O3, it has a molar mass of 248.28 g/mol. Systematically, it is named 2,3-dihydro-1,4-benzodioxin-3-yl(piperazin-1-yl)methanone. Alternative names: N-1,4-Benzodioxane-2-carbonyl piperazine and 1-(1,4-benzodioxane-2-carbonyl)piperazine.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

Pharmaceutical QC and development laboratories use this impurity standard of Doxazosin to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 1-(1,4-Benzodioxan-2-ylcarbonyl)piperazine is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Doxazosin

View every impurity, metabolite and intermediate we list for Doxazosin.

Doxazosin impurities

Specifications & identifiers

Chemical identifiers
Product name	1-(1,4-Benzodioxan-2-ylcarbonyl)piperazine
Catalogue No.	VQ-048087
CAS Number	70918-00-2
IUPAC name	2,3-dihydro-1,4-benzodioxin-3-yl(piperazin-1-yl)methanone
Molecular formula	C₁₃H₁₆N₂O₃
Molecular weight	248.28 g/mol
Exact mass	248.1161
Grade	Reference Standard
HSN code	38229090
InChIKey	FLUPDJNTYCSBJZ-UHFFFAOYSA-N
SMILES	C1CN(CCN1)C(=O)C2COC3=CC=CC=C3O2
PubChem CID	2735449

Physical properties
Physical form	Solid
LogP (XLogP3)	0.7
H-bond donors / acceptors	1 / 4
TPSA	50.8 Å²
Synonyms	(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone, N-1,4-Benzodioxane-2-carbonyl piperazine, 2,3-dihydro-1,4-benzodioxin-2-yl(piperazin-1-yl)methanone, Piperazine, 1-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]-, 1-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine, (2,3-Dihydrobenzo(1,4)dioxin-2-yl)piperazin-1-yl-methanone, 1-[(2rs)-2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl]piperazine, 1-(1,4-benzodioxane-2-carbonyl)piperazine, 2-(1-Piperazinylcarbonyl)-1,4-benzodioxane, (2,3-dihydro-benzo[1,4]dioxin-2-yl)-piperazin-1-yl-methanone, n-[(1,4-benzodioxan-2-yl)carbonyl]piperazine, 1,4-Benzodioxan-2-carboxypiperazine

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Health hazard

Environmental hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H302Harmful if swallowed
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
H373May causes damage to organs through prolonged or repeated exposure
H411Toxic to aquatic life with long lasting effects

Precautionary statements: P260, P261, P262, P264, P264 + P265, P270, P271, P273, P280, P301 + P316, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P316, P319, P321, P330, P332 + P317, P337 + P317, P361 + P364, P362 + P364, P391, P403 + P233

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 1-(1,4-Benzodioxan-2-ylcarbonyl)piperazine?

The CAS Registry Number of 1-(1,4-Benzodioxan-2-ylcarbonyl)piperazine is 70918-00-2. It is also known as (2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone, N-1,4-Benzodioxane-2-carbonyl piperazine, 2,3-dihydro-1,4-benzodioxin-2-yl(piperazin-1-yl)methanone.

What is the molecular formula and molecular weight of 1-(1,4-Benzodioxan-2-ylcarbonyl)piperazine?

1-(1,4-Benzodioxan-2-ylcarbonyl)piperazine has the molecular formula C13H16N2O3 and a molecular weight of 248.28 g/mol. Its IUPAC name is 2,3-dihydro-1,4-benzodioxin-3-yl(piperazin-1-yl)methanone.

What is 1-(1,4-Benzodioxan-2-ylcarbonyl)piperazine used for?

1-(1,4-Benzodioxan-2-ylcarbonyl)piperazine is supplied as a characterised reference material related to Doxazosin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 1-(1,4-Benzodioxan-2-ylcarbonyl)piperazine can I order?

We supply 1-(1,4-Benzodioxan-2-ylcarbonyl)piperazine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 1-(1,4-Benzodioxan-2-ylcarbonyl)piperazine?

Yes. Every lot of 1-(1,4-Benzodioxan-2-ylcarbonyl)piperazine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 1-(1,4-Benzodioxan-2-ylcarbonyl)piperazine be shipped internationally?

Yes. 1-(1,4-Benzodioxan-2-ylcarbonyl)piperazine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.