2,4-Difluorobenzylamine

About 2,4-Difluorobenzylamine

2,4-Difluorobenzylamine is an impurity of Dolutegravir carrying the CAS registry number 72235-52-0. Formula C7H7F2N, molecular weight 143.13 g/mol. Systematically, it is named (2,4-difluorophenyl)methanamine. Common synonyms include Benzenemethanamine, 2,4-difluoro- and 2,4-difluorobenzenemethanamine.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

This Dolutegravir impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer 2,4-Difluorobenzylamine in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Dolutegravir

View every impurity, metabolite and intermediate we list for Dolutegravir.

Dolutegravir impurities

Specifications & identifiers

Chemical identifiers
Product name	2,4-Difluorobenzylamine
Catalogue No.	VQ-027195
CAS Number	72235-52-0
IUPAC name	(2,4-difluorophenyl)methanamine
Molecular formula	C₇H₇F₂N
Molecular weight	143.13 g/mol
Exact mass	143.0547
Grade	Reference Standard
HSN code	38229090
InChIKey	QDZZDVQGBKTLHV-UHFFFAOYSA-N
SMILES	C1=CC(=C(C=C1F)F)CN
PubChem CID	2733244

Physical properties
Physical form	Solid
LogP (XLogP3)	1
H-bond donors / acceptors	1 / 3
TPSA	26 Å²
Synonyms	Benzenemethanamine, 2,4-difluoro-, 2,4-difluorobenzenemethanamine, 1-(2,4-difluorophenyl)methanamine, N-difluorobenzylamine, 2,4-difluorbenzylamine

Safety & hazard information (GHS)

Corrosive

Signal word: Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements: P260, P264, P280, P301 + P330 + P331, P302 + P361 + P354, P304 + P340, P305 + P354 + P338, P316, P321, P363, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2,4-Difluorobenzylamine?

The CAS Registry Number of 2,4-Difluorobenzylamine is 72235-52-0. It is also known as Benzenemethanamine, 2,4-difluoro-, 2,4-difluorobenzenemethanamine, 1-(2,4-difluorophenyl)methanamine.

What is the molecular formula and molecular weight of 2,4-Difluorobenzylamine?

2,4-Difluorobenzylamine has the molecular formula C7H7F2N and a molecular weight of 143.13 g/mol. Its IUPAC name is (2,4-difluorophenyl)methanamine.

What is 2,4-Difluorobenzylamine used for?

2,4-Difluorobenzylamine is supplied as a characterised reference material related to Dolutegravir. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2,4-Difluorobenzylamine can I order?

We supply 2,4-Difluorobenzylamine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2,4-Difluorobenzylamine?

Yes. Every lot of 2,4-Difluorobenzylamine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2,4-Difluorobenzylamine be shipped internationally?

Yes. 2,4-Difluorobenzylamine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.