5-(Trifluoromethyl)-2-(chloromethyl)-1,3,4-ox… 723286-98-4

About 5-(Trifluoromethyl)-2-(chloromethyl)-1,3,4-oxadiazole

5-(Trifluoromethyl)-2-(chloromethyl)-1,3,4-oxadiazole is an impurity of Sitagliptin carrying the CAS registry number 723286-98-4. With the molecular formula C4H2ClF3N2O, it has a molar mass of 186.52 g/mol. The IUPAC name is 2-(chloromethyl)-5-(trifluoromethyl)-1,3,4-oxadiazole. It is also known as 2-Chloromethyl-5-t or CS-M0690.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

This Sitagliptin impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Sitagliptin

View every impurity, metabolite and intermediate we list for Sitagliptin.

Sitagliptin impurities

Specifications & identifiers

Chemical identifiers
Product name	5-(Trifluoromethyl)-2-(chloromethyl)-1,3,4-oxadiazole
Catalogue No.	VQ-028054
CAS Number	723286-98-4
IUPAC name	2-(chloromethyl)-5-(trifluoromethyl)-1,3,4-oxadiazole
Molecular formula	C₄H₂ClF₃N₂O
Molecular weight	186.52 g/mol
Exact mass	185.9808
Grade	Reference Standard
HSN code	38229090
InChIKey	GPXSXZGMVOSWMN-UHFFFAOYSA-N
SMILES	C(C1=NN=C(O1)C(F)(F)F)Cl
PubChem CID	10442445

Physical properties
Physical form	Solid
LogP (XLogP3)	1.1
H-bond donors / acceptors	0 / 6
TPSA	38.9 Å²
Synonyms	5-(Chloromethyl)-2-(trifluoromethyl)-1,3,4-oxadiazole, 1,3,4-oxadiazole, 2-(chloromethyl)-5-(trifluoromethyl)-, 2-Chloromethyl-5-trifluoromethyl-1,3,4-oxadiazole, 2-Chloromethyl-5-t, 2-(Chloromethyl)-5-(trifluromethyl)-1,3,4-oxadiazole, CS-M0690, 2-chloromethyl-5-trifluoromethyl-1,3,4-oxadia-zole

Safety & hazard information (GHS)

Corrosive

Harmful / irritant

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H314Causes severe skin burns and eye damage
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P260, P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P301 + P330 + P331, P302 + P352, P302 + P361 + P354, P304 + P340, P305 + P351 + P338, P305 + P354 + P338, P316, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P363, P403 + P233, P405

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 5-(Trifluoromethyl)-2-(chloromethyl)-1,3,4-oxadiazole?

The CAS Registry Number of 5-(Trifluoromethyl)-2-(chloromethyl)-1,3,4-oxadiazole is 723286-98-4. It is also known as 5-(Chloromethyl)-2-(trifluoromethyl)-1,3,4-oxadiazole, 1,3,4-oxadiazole, 2-(chloromethyl)-5-(trifluoromethyl)-, 2-Chloromethyl-5-trifluoromethyl-1,3,4-oxadiazole.

What is the molecular formula and molecular weight of 5-(Trifluoromethyl)-2-(chloromethyl)-1,3,4-oxadiazole?

5-(Trifluoromethyl)-2-(chloromethyl)-1,3,4-oxadiazole has the molecular formula C4H2ClF3N2O and a molecular weight of 186.52 g/mol. Its IUPAC name is 2-(chloromethyl)-5-(trifluoromethyl)-1,3,4-oxadiazole.

What is 5-(Trifluoromethyl)-2-(chloromethyl)-1,3,4-oxadiazole used for?

5-(Trifluoromethyl)-2-(chloromethyl)-1,3,4-oxadiazole is supplied as a characterised reference material related to Sitagliptin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 5-(Trifluoromethyl)-2-(chloromethyl)-1,3,4-oxadiazole can I order?

We supply 5-(Trifluoromethyl)-2-(chloromethyl)-1,3,4-oxadiazole in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 5-(Trifluoromethyl)-2-(chloromethyl)-1,3,4-oxadiazole?

Yes. Every lot of 5-(Trifluoromethyl)-2-(chloromethyl)-1,3,4-oxadiazole is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 5-(Trifluoromethyl)-2-(chloromethyl)-1,3,4-oxadiazole be shipped internationally?

Yes. 5-(Trifluoromethyl)-2-(chloromethyl)-1,3,4-oxadiazole is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.