Diethylene Glycol Di(p-toluenesulfonate)

Name: Diethylene Glycol Di(p-toluenesulfonate)
Brand: Vaqora Chemicals
SKU: VQ-037651

About Diethylene Glycol Di(p-toluenesulfonate)

Vaqora Chemicals supplies Diethylene Glycol Di(p-toluenesulfonate), an impurity of Icotinib registered under CAS number 7460-82-4. The compound has the formula C18H22O7S2, corresponding to a molecular weight of 414.5 g/mol. Its systematic (IUPAC) name is 2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethyl 4-methylbenzenesulfonate. It is also known as Diethylene Glycol Bis(p-toluenesulfonate) or Diethylene glycol ditosylate.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Icotinib to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Diethylene Glycol Di(p-toluenesulfonate) is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Icotinib

View every impurity, metabolite and intermediate we list for Icotinib.

Icotinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Diethylene Glycol Di(p-toluenesulfonate)
Catalogue No.	VQ-037651
CAS Number	7460-82-4
IUPAC name	2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethyl 4-methylbenzenesulfonate
Molecular formula	C₁₈H₂₂O₇S₂
Molecular weight	414.5 g/mol
Exact mass	414.0807
Grade	Reference Standard
HSN code	38229090
InChIKey	VYVPNTJBGPQTFA-UHFFFAOYSA-N
SMILES	CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOS(=O)(=O)C2=CC=C(C=C2)C
PubChem CID	316659

Physical properties
Physical form	Solid
LogP (XLogP3)	2.8
H-bond donors / acceptors	0 / 7
TPSA	113 Å²
Synonyms	Diethylene Glycol Bis(p-toluenesulfonate), Diethylene glycol ditosylate, Ethanol, 2,2'-oxybis-, bis(4-methylbenzenesulfonate), diethyleneglycol-di-p-tosylate, Oxybis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate), 2-{2-[(4-methylbenzenesulfonyl)oxy]ethoxy}ethyl 4-methylbenzene-1-sulfonate, Bis(2-tosyloxyethyl)ether, CBMicro_047760, 2,2'-Oxydiethyl ditosylate, di(2-tosyloxyethyl)ether, 2-{2-[(4-methylphenyl)sulfonyloxy]ethoxy}ethyl 4-methylbenzenesulfonate, diethyleneglycol ditosylate

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Diethylene Glycol Di(p-toluenesulfonate)?

The CAS Registry Number of Diethylene Glycol Di(p-toluenesulfonate) is 7460-82-4. It is also known as Diethylene Glycol Bis(p-toluenesulfonate), Diethylene glycol ditosylate, Ethanol, 2,2'-oxybis-, bis(4-methylbenzenesulfonate).

What is the molecular formula and molecular weight of Diethylene Glycol Di(p-toluenesulfonate)?

Diethylene Glycol Di(p-toluenesulfonate) has the molecular formula C18H22O7S2 and a molecular weight of 414.5 g/mol. Its IUPAC name is 2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethyl 4-methylbenzenesulfonate.

What is Diethylene Glycol Di(p-toluenesulfonate) used for?

Diethylene Glycol Di(p-toluenesulfonate) is supplied as a characterised reference material related to Icotinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Diethylene Glycol Di(p-toluenesulfonate) can I order?

We supply Diethylene Glycol Di(p-toluenesulfonate) in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Diethylene Glycol Di(p-toluenesulfonate)?

Yes. Every lot of Diethylene Glycol Di(p-toluenesulfonate) is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Diethylene Glycol Di(p-toluenesulfonate) be shipped internationally?

Yes. Diethylene Glycol Di(p-toluenesulfonate) is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.