2-Methyl-2-nitro-1,3-propanediol

About 2-Methyl-2-nitro-1,3-propanediol

2-Methyl-2-nitro-1,3-propanediol is an impurity of Bronopol carrying the CAS registry number 77-49-6. Formula C4H9NO4, molecular weight 135.12 g/mol. Systematically, it is named 2-methyl-2-nitropropane-1,3-diol. Alternative names: Nitroisobutylglycol and 2-Nitro-2-methyl-1,3-propanediol.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Warning” with 1 hazard statement. Review the Safety Data Sheet before use.

This Bronopol impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 2-Methyl-2-nitro-1,3-propanediol is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Bronopol

View every impurity, metabolite and intermediate we list for Bronopol.

Bronopol impurities

Specifications & identifiers

Chemical identifiers
Product name	2-Methyl-2-nitro-1,3-propanediol
Catalogue No.	VQ-027235
CAS Number	77-49-6
IUPAC name	2-methyl-2-nitropropane-1,3-diol
Molecular formula	C₄H₉NO₄
Molecular weight	135.12 g/mol
Exact mass	135.0532
Grade	Reference Standard
HSN code	38229090
InChIKey	LOTYADDQWWVBDJ-UHFFFAOYSA-N
SMILES	CC(CO)(CO)[N+](=O)[O-]
PubChem CID	6480

Physical properties
Physical form	Solid
LogP (XLogP3)	-1.1
H-bond donors / acceptors	2 / 4
TPSA	86.3 Å²
Synonyms	Nitroisobutylglycol, 2-Nitro-2-methyl-1,3-propanediol, 1,3-Propanediol, 2-methyl-2-nitro-, 1,1-Dimethylol-1-nitroethane, 2-Methyl-2-nitropropanediol, 2-Methyl-2-Nitro-Propane-1,3-Diol, 1, 2-methyl-2-nitro-

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements: P264 + P265, P280, P305 + P351 + P338, P337 + P317

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2-Methyl-2-nitro-1,3-propanediol?

The CAS Registry Number of 2-Methyl-2-nitro-1,3-propanediol is 77-49-6. It is also known as Nitroisobutylglycol, 2-Nitro-2-methyl-1,3-propanediol, 1,3-Propanediol, 2-methyl-2-nitro-.

What is the molecular formula and molecular weight of 2-Methyl-2-nitro-1,3-propanediol?

2-Methyl-2-nitro-1,3-propanediol has the molecular formula C4H9NO4 and a molecular weight of 135.12 g/mol. Its IUPAC name is 2-methyl-2-nitropropane-1,3-diol.

What is 2-Methyl-2-nitro-1,3-propanediol used for?

2-Methyl-2-nitro-1,3-propanediol is supplied as a characterised reference material related to Bronopol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2-Methyl-2-nitro-1,3-propanediol can I order?

We supply 2-Methyl-2-nitro-1,3-propanediol in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2-Methyl-2-nitro-1,3-propanediol?

Yes. Every lot of 2-Methyl-2-nitro-1,3-propanediol is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2-Methyl-2-nitro-1,3-propanediol be shipped internationally?

Yes. 2-Methyl-2-nitro-1,3-propanediol is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.