4-Hydroxy-L-isoleucine

Name: 4-Hydroxy-L-isoleucine
Brand: Vaqora Chemicals
SKU: VQ-032412

About 4-Hydroxy-L-isoleucine

4-Hydroxy-L-isoleucine is a metabolite or degradation product of Leucine carrying the CAS registry number 781658-23-9. Its molecular formula is C6H13NO3 and its molecular weight is 147.17 g/mol. Systematically, it is named (2S,3R)-2-amino-4-hydroxy-3-methylpentanoic acid. It is also known as 4-Hydroxy Isoleucine or 4-Hydroxyisoleucine.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Analytical teams use this compound to identify metabolites and degradants of Leucine, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies 4-Hydroxy-L-isoleucine in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling
Fine chemical synthesis

Industries

Related to Leucine

View every impurity, metabolite and intermediate we list for Leucine.

Leucine impurities

Specifications & identifiers

Chemical identifiers
Product name	4-Hydroxy-L-isoleucine
Catalogue No.	VQ-032412
CAS Number	781658-23-9
IUPAC name	(2S,3R)-2-amino-4-hydroxy-3-methylpentanoic acid
Molecular formula	C₆H₁₃NO₃
Molecular weight	147.17 g/mol
Exact mass	147.0895
Grade	Reference Standard
HSN code	38229090
InChIKey	OSCCDBFHNMXNME-DSDZBIDZSA-N
SMILES	C[C@H]([C@@H](C(=O)O)N)C(C)O
PubChem CID	2773624

Physical properties
Physical form	Solid
LogP (XLogP3)	-2.8
H-bond donors / acceptors	3 / 4
TPSA	83.6 Å²
Synonyms	4-Hydroxy Isoleucine, 4-Hydroxyisoleucine, L-4-Hydroxyisoleucine, 4-Hydoxy-l-isoleucine, 4-ydroxy--soleucine, (2S,3R)-2-amino-4-hydroxy-3-methyl-pentanoic acid, Rel-(2S,3R)-2-amino-4-hydroxy-3-methylpentanoic acid

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4-Hydroxy-L-isoleucine?

The CAS Registry Number of 4-Hydroxy-L-isoleucine is 781658-23-9. It is also known as 4-Hydroxy Isoleucine, 4-Hydroxyisoleucine, L-4-Hydroxyisoleucine.

What is the molecular formula and molecular weight of 4-Hydroxy-L-isoleucine?

4-Hydroxy-L-isoleucine has the molecular formula C6H13NO3 and a molecular weight of 147.17 g/mol. Its IUPAC name is (2S,3R)-2-amino-4-hydroxy-3-methylpentanoic acid.

What is 4-Hydroxy-L-isoleucine used for?

4-Hydroxy-L-isoleucine is supplied as a characterised reference material related to Leucine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4-Hydroxy-L-isoleucine can I order?

We supply 4-Hydroxy-L-isoleucine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4-Hydroxy-L-isoleucine?

Yes. Every lot of 4-Hydroxy-L-isoleucine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4-Hydroxy-L-isoleucine be shipped internationally?

Yes. 4-Hydroxy-L-isoleucine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.