Threo Dihydro Bupropion Hydrochloride

Name: Threo Dihydro Bupropion Hydrochloride
Brand: Vaqora Chemicals
SKU: VQ-036048

About Threo Dihydro Bupropion Hydrochloride

Listed under CAS 80478-42-8, Threo Dihydro Bupropion Hydrochloride is a metabolite or degradation product of Bupropion available from Vaqora Chemicals. Its molecular formula is C13H21Cl2NO and its molecular weight is 278.21 g/mol. Alternative names: threo-Hydroxy Bupropion Hydrochloride and Threohydroxy Bupropion Hydrochloride.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Warning” with 1 hazard statement. Review the Safety Data Sheet before use.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Bupropion, as well as in QC testing and ANDA/DMF documentation. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Bupropion

View every impurity, metabolite and intermediate we list for Bupropion.

Bupropion impurities

Specifications & identifiers

Chemical identifiers
Product name	Threo Dihydro Bupropion Hydrochloride
Catalogue No.	VQ-036048
CAS Number	80478-42-8
IUPAC name	(1S,2S)-2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-ol;hydrochloride
Molecular formula	C₁₃H₂₁Cl₂NO
Molecular weight	278.21 g/mol
Exact mass	277.1
Grade	Reference Standard
HSN code	38229090
InChIKey	YZHVQDVGTAELNB-PKKHVXKMSA-N
SMILES	C[C@@H]([C@H](C1=CC(=CC=C1)Cl)O)NC(C)(C)C.Cl
PubChem CID	9878737

Physical properties
Physical form	Solid
H-bond donors / acceptors	3 / 2
TPSA	32.3 Å²
Synonyms	threo-Hydroxy Bupropion Hydrochloride, Threohydroxy Bupropion Hydrochloride, (1R,2R)-1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanol hydrochloride, (1R,2R)-1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanol hydrochloride, rac threo-Dihydro Bupropion Hydrochloride, (S,S)-Dihydro Bupropion Hydrochloride, rac threo-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-ol Hydrochloride, Bupropion Dihydro (S,S)-Isomer (HCl)

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements: P264, P270, P301 + P317, P330, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Threo Dihydro Bupropion Hydrochloride?

The CAS Registry Number of Threo Dihydro Bupropion Hydrochloride is 80478-42-8. It is also known as threo-Hydroxy Bupropion Hydrochloride, Threohydroxy Bupropion Hydrochloride, (1R,2R)-1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanol hydrochloride.

What is the molecular formula and molecular weight of Threo Dihydro Bupropion Hydrochloride?

Threo Dihydro Bupropion Hydrochloride has the molecular formula C13H21Cl2NO and a molecular weight of 278.21 g/mol.

What is Threo Dihydro Bupropion Hydrochloride used for?

Threo Dihydro Bupropion Hydrochloride is supplied as a characterised reference material related to Bupropion. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Threo Dihydro Bupropion Hydrochloride can I order?

We supply Threo Dihydro Bupropion Hydrochloride in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Threo Dihydro Bupropion Hydrochloride?

Yes. Every lot of Threo Dihydro Bupropion Hydrochloride is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Threo Dihydro Bupropion Hydrochloride be shipped internationally?

Yes. Threo Dihydro Bupropion Hydrochloride is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.