rac-N-Nitroso Nornicotine

About rac-N-Nitroso Nornicotine

rac-N-Nitroso Nornicotine is a nitrosamine impurity of Nicotine carrying the CAS registry number 80508-23-2. The compound has the formula C9H11N3O, corresponding to a molecular weight of 177.2 g/mol. The IUPAC name is 3-(1-nitrosopyrrolidin-2-yl)pyridine. It is also known as 3-(1-Nitroso-2-pyrrolidinyl)pyridine or Pyridine, 3-(1-nitroso-2-pyrrolidinyl)-.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. It carries the GHS signal word “Danger” with 2 hazard statements. Review the Safety Data Sheet before use.

Laboratories use this nitrosamine standard to develop and validate highly sensitive LC-MS/MS methods, to confirm limits of detection and to document nitrosamine risk assessments in regulatory submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, rac-N-Nitroso Nornicotine is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Nicotine

View every impurity, metabolite and intermediate we list for Nicotine.

Nicotine impurities

Specifications & identifiers

Chemical identifiers
Product name	rac-N-Nitroso Nornicotine
Catalogue No.	VQ-032143
CAS Number	80508-23-2
IUPAC name	3-(1-nitrosopyrrolidin-2-yl)pyridine
Molecular formula	C₉H₁₁N₃O
Molecular weight	177.2 g/mol
Exact mass	177.0902
Grade	Reference Standard
HSN code	38229090
InChIKey	XKABJYQDMJTNGQ-UHFFFAOYSA-N
SMILES	C1CC(N(C1)N=O)C2=CN=CC=C2
PubChem CID	27919

Physical properties
Physical form	Solid
LogP (XLogP3)	1.1
H-bond donors / acceptors	0 / 4
TPSA	45.6 Å²
Synonyms	3-(1-Nitroso-2-pyrrolidinyl)pyridine, Pyridine, 3-(1-nitroso-2-pyrrolidinyl)-, Nitrosonornikotin, N'-Nitrosonornicotin, Nornicotine, N-nitroso, N(2)-Nitrosonornicotine, N inverted exclamation marka-Nitrosonornicotine

Safety & hazard information (GHS)

Toxic

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H351Suspected of causing cancer

Precautionary statements: P203, P264, P270, P280, P301 + P316, P318, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of rac-N-Nitroso Nornicotine?

The CAS Registry Number of rac-N-Nitroso Nornicotine is 80508-23-2. It is also known as 3-(1-Nitroso-2-pyrrolidinyl)pyridine, Pyridine, 3-(1-nitroso-2-pyrrolidinyl)-, Nitrosonornikotin.

What is the molecular formula and molecular weight of rac-N-Nitroso Nornicotine?

rac-N-Nitroso Nornicotine has the molecular formula C9H11N3O and a molecular weight of 177.2 g/mol. Its IUPAC name is 3-(1-nitrosopyrrolidin-2-yl)pyridine.

What is rac-N-Nitroso Nornicotine used for?

rac-N-Nitroso Nornicotine is supplied as a characterised reference material related to Nicotine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of rac-N-Nitroso Nornicotine can I order?

We supply rac-N-Nitroso Nornicotine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with rac-N-Nitroso Nornicotine?

Yes. Every lot of rac-N-Nitroso Nornicotine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can rac-N-Nitroso Nornicotine be shipped internationally?

Yes. rac-N-Nitroso Nornicotine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.