N-Desmethyl Regorafenib N-Oxide

About N-Desmethyl Regorafenib N-Oxide

N-Desmethyl Regorafenib N-Oxide is a metabolite or degradation product of Regorafenib carrying the CAS registry number 835621-12-0. Formula C20H13ClF4N4O4, molecular weight 484.8 g/mol. The IUPAC name is 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-1-oxidopyridin-1-ium-2-carboxamide. Alternative names: Regorafenib metabolite M5 and Regorafenib N-oxide and N-desmethyl (M5).

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Analytical teams use this compound to identify metabolites and degradants of Regorafenib, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer N-Desmethyl Regorafenib N-Oxide in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Regorafenib

View every impurity, metabolite and intermediate we list for Regorafenib.

Regorafenib impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Desmethyl Regorafenib N-Oxide
Catalogue No.	VQ-027766
CAS Number	835621-12-0
IUPAC name	4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-1-oxidopyridin-1-ium-2-carboxamide
Molecular formula	C₂₀H₁₃ClF₄N₄O₄
Molecular weight	484.8 g/mol
Exact mass	484.0561
Grade	Reference Standard
HSN code	38229090
InChIKey	JPEWXTSDCNCZOD-UHFFFAOYSA-N
SMILES	C1=CC(=C(C=C1NC(=O)NC2=C(C=C(C=C2)OC3=CC(=[N+](C=C3)[O-])C(=O)N)F)C(F)(F)F)Cl
PubChem CID	53491673

Physical properties
Physical form	Solid
LogP (XLogP3)	3.3
H-bond donors / acceptors	3 / 8
TPSA	119 Å²
Synonyms	N-Desmethyl Regorafenib N-Oxide (M5 Metabolite), Regorafenib metabolite M5, Regorafenib N-oxide and N-desmethyl (M5), N-Desmethyl Regorafenib (Pyridine)-N-oxide, Regorafenib N-Desmethyl Pyridine-N-Oxide, Regorafenib metabolite M5 (N-oxide, N-desmethyl)

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Desmethyl Regorafenib N-Oxide?

The CAS Registry Number of N-Desmethyl Regorafenib N-Oxide is 835621-12-0. It is also known as N-Desmethyl Regorafenib N-Oxide (M5 Metabolite), Regorafenib metabolite M5, Regorafenib N-oxide and N-desmethyl (M5).

What is the molecular formula and molecular weight of N-Desmethyl Regorafenib N-Oxide?

N-Desmethyl Regorafenib N-Oxide has the molecular formula C20H13ClF4N4O4 and a molecular weight of 484.8 g/mol. Its IUPAC name is 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-1-oxidopyridin-1-ium-2-carboxamide.

What is N-Desmethyl Regorafenib N-Oxide used for?

N-Desmethyl Regorafenib N-Oxide is supplied as a characterised reference material related to Regorafenib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Desmethyl Regorafenib N-Oxide can I order?

We supply N-Desmethyl Regorafenib N-Oxide in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Desmethyl Regorafenib N-Oxide?

Yes. Every lot of N-Desmethyl Regorafenib N-Oxide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Desmethyl Regorafenib N-Oxide be shipped internationally?

Yes. We export N-Desmethyl Regorafenib N-Oxide worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.