Cetirizine Impurity F (Dihydrochloride)

About Cetirizine Impurity F (Dihydrochloride)

Cetirizine Impurity F (Dihydrochloride) is an impurity of Cetirizine carrying the CAS registry number 83881-54-3. With the molecular formula C21H28Cl2N2O3, it has a molar mass of 427.4 g/mol. Systematically, it is named 2-[2-(4-benzhydrylpiperazin-1-yl)ethoxy]acetic acid. Dihydrochloride. It is also known as Deschloro Cetirizine Dihydrochloride or Cetirizine EP Impurity F Dihydrochloride.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

As a characterised impurity of Cetirizine, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer Cetirizine Impurity F (Dihydrochloride) in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Cetirizine

View every impurity, metabolite and intermediate we list for Cetirizine.

Cetirizine impurities

Specifications & identifiers

Chemical identifiers
Product name	Cetirizine Impurity F (Dihydrochloride)
Catalogue No.	VQ-004633
CAS Number	83881-54-3
IUPAC name	2-[2-(4-benzhydrylpiperazin-1-yl)ethoxy]acetic acid;dihydrochloride
Molecular formula	C₂₁H₂₈Cl₂N₂O₃
Molecular weight	427.4 g/mol
Exact mass	426.1477
Grade	Reference Standard
HSN code	38229090
InChIKey	KODBQWPTPNAKJM-UHFFFAOYSA-N
SMILES	C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=CC=C3.Cl.Cl
PubChem CID	3068852

Physical properties
Physical form	Solid
H-bond donors / acceptors	3 / 5
TPSA	53 Å²
Synonyms	Deschloro Cetirizine Dihydrochloride, 2-[2-[4-(Diphenylmethyl)-1-piperazinyl]ethoxy]acetic Acid DiHydrochloride, [2-[4-(Diphenylmethyl)-1-piperazinyl]ethoxy]acetic Acid Dihydrochloride, Cetirizine EP Impurity F Dihydrochloride, (2-(2-(4-(Diphenylmethyl)-1-piperazinyl)ethoxy)ethoxy)acetic acid dihydrochloride, Acetic acid, (2-(2-(4-(diphenylmethyl)-1-piperazinyl)ethoxy)ethoxy)-, dihydrochloride, Deschloro Cetirizine (dihydrochloride), 2-{2-[4-(diphenylmethyl)piperazin-1-yl]ethoxy}acetic acid dihydrochloride, [2-[4-(Diphenylmethyl)piperazin-1-yl]ethoxy]acetic Acid Dihydrochloride, 83881-53-2(free base), Cetirizine EP Impurity F(2HCl), DeschloroCetirizine(dihydrochloride)

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements: P264, P270, P301 + P317, P330, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Cetirizine Impurity F (Dihydrochloride)?

The CAS Registry Number of Cetirizine Impurity F (Dihydrochloride) is 83881-54-3. It is also known as Deschloro Cetirizine Dihydrochloride, 2-[2-[4-(Diphenylmethyl)-1-piperazinyl]ethoxy]acetic Acid DiHydrochloride, [2-[4-(Diphenylmethyl)-1-piperazinyl]ethoxy]acetic Acid Dihydrochloride.

What is the molecular formula and molecular weight of Cetirizine Impurity F (Dihydrochloride)?

Cetirizine Impurity F (Dihydrochloride) has the molecular formula C21H28Cl2N2O3 and a molecular weight of 427.4 g/mol.

What is Cetirizine Impurity F (Dihydrochloride) used for?

Cetirizine Impurity F (Dihydrochloride) is supplied as a characterised reference material related to Cetirizine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Cetirizine Impurity F (Dihydrochloride) can I order?

We supply Cetirizine Impurity F (Dihydrochloride) in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Cetirizine Impurity F (Dihydrochloride)?

Yes. Every lot of Cetirizine Impurity F (Dihydrochloride) is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Cetirizine Impurity F (Dihydrochloride) be shipped internationally?

Yes. Cetirizine Impurity F (Dihydrochloride) is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.