Methyl 2,6-difluoro-3-nitrobenzoate

About Methyl 2,6-difluoro-3-nitrobenzoate

Methyl 2,6-difluoro-3-nitrobenzoate is an impurity of Vemurafenib carrying the CAS registry number 84832-01-9. Formula C8H5F2NO4, molecular weight 217.13 g/mol. Common synonyms include 2,6-Difluoro-3-nitrobenzoic acid methyl ester.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 2 hazard statements. Review the Safety Data Sheet before use.

This Vemurafenib impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Vemurafenib

View every impurity, metabolite and intermediate we list for Vemurafenib.

Vemurafenib impurities

Specifications & identifiers

Chemical identifiers
Product name	Methyl 2,6-difluoro-3-nitrobenzoate
Catalogue No.	VQ-044976
CAS Number	84832-01-9
IUPAC name	methyl 2,6-difluoro-3-nitrobenzoate
Molecular formula	C₈H₅F₂NO₄
Molecular weight	217.13 g/mol
Exact mass	217.0187
Grade	Reference Standard
HSN code	38229090
InChIKey	CIHHBTMZOLRCRL-UHFFFAOYSA-N
SMILES	COC(=O)C1=C(C=CC(=C1F)[N+](=O)[O-])F
PubChem CID	43449035

Physical properties
Physical form	Solid
LogP (XLogP3)	1.8
H-bond donors / acceptors	0 / 6
TPSA	72.1 Å²

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation

Precautionary statements: P264, P264 + P265, P280, P302 + P352, P305 + P351 + P338, P321, P332 + P317, P337 + P317, P362 + P364

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Methyl 2,6-difluoro-3-nitrobenzoate?

The CAS Registry Number of Methyl 2,6-difluoro-3-nitrobenzoate is 84832-01-9. It is also known as 2,6-Difluoro-3-nitrobenzoic acid methyl ester, Benzoic acid,2,6-difluoro-3-nitro-, methyl ester, Benzoic acid, 2,6-difluoro-3-nitro-, methyl ester.

What is the molecular formula and molecular weight of Methyl 2,6-difluoro-3-nitrobenzoate?

Methyl 2,6-difluoro-3-nitrobenzoate has the molecular formula C8H5F2NO4 and a molecular weight of 217.13 g/mol. Its IUPAC name is methyl 2,6-difluoro-3-nitrobenzoate.

What is Methyl 2,6-difluoro-3-nitrobenzoate used for?

Methyl 2,6-difluoro-3-nitrobenzoate is supplied as a characterised reference material related to Vemurafenib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Methyl 2,6-difluoro-3-nitrobenzoate can I order?

We supply Methyl 2,6-difluoro-3-nitrobenzoate in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Methyl 2,6-difluoro-3-nitrobenzoate?

Yes. Every lot of Methyl 2,6-difluoro-3-nitrobenzoate is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Methyl 2,6-difluoro-3-nitrobenzoate be shipped internationally?

Yes. Methyl 2,6-difluoro-3-nitrobenzoate is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.