Cetirizine Impurity D (Dihydrochloride)

About Cetirizine Impurity D (Dihydrochloride)

Cetirizine Impurity D (Dihydrochloride) is an impurity of Cetirizine carrying the CAS registry number 856841-95-7. Its molecular formula is C30H28Cl2N2 and its molecular weight is 487.5 g/mol. Its systematic (IUPAC) name is 1,4-bis[(4-chlorophenyl)-phenylmethyl]piperazine. Common synonyms include Cetirizine Dimer Dihydrochloride and USP Cetirizine Dimer Dihydrochloride.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 6 hazard statements. Review the Safety Data Sheet before use.

Pharmaceutical QC and development laboratories use this impurity standard of Cetirizine to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Cetirizine Impurity D (Dihydrochloride) is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Cetirizine

View every impurity, metabolite and intermediate we list for Cetirizine.

Cetirizine impurities

Specifications & identifiers

Chemical identifiers
Product name	Cetirizine Impurity D (Dihydrochloride)
Catalogue No.	VQ-004630
CAS Number	856841-95-7
IUPAC name	1,4-bis[(4-chlorophenyl)-phenylmethyl]piperazine
Molecular formula	C₃₀H₂₈Cl₂N₂
Molecular weight	487.5 g/mol
Exact mass	486.163
Grade	Reference Standard
HSN code	38229090
InChIKey	ZHKWYPRSELVIIG-UHFFFAOYSA-N
SMILES	C1CN(CCN1C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl)C(C4=CC=CC=C4)C5=CC=C(C=C5)Cl
PubChem CID	413327

Physical properties
Physical form	Solid
LogP (XLogP3)	7.7
H-bond donors / acceptors	0 / 2
TPSA	6.5 Å²
Synonyms	Cetirizine Dimer Dihydrochloride, 1,4-Bis[(4-chlorophenyl)phenylmethyl]piperazine Dihydrochloride, USP Cetirizine Dimer Dihydrochloride, Cetririzine EP Impurity D Dihydrochloride, 1,4-bis[(4-chlorophenyl)phenylmethyl]piperazine, 1,4-Bis((4-chlorophenyl)phenylmethyl)piperazine, 1,4-bis((4-chlorophenyl)(phenyl)methyl)piperazine, 1,4-bis[(4-chlorophenyl)(phenyl)methyl]piperazine, Cetirizine impurity D, Cetirizine dimer, Piperazine, 1,4-bis((4-chlorophenyl)phenylmethyl)-, 1,4-bis(4-Chlorobenzhydryl)piperazine

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Environmental hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H319Causes serious eye irritation
H335May cause respiratory irritation
H361Suspected of damaging fertility or the unborn child
H400Very toxic to aquatic life

Precautionary statements: P203, P261, P264, P264 + P265, P270, P271, P273, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P318, P319, P321, P330, P337 + P317, P362 + P364, P391, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Cetirizine Impurity D (Dihydrochloride)?

The CAS Registry Number of Cetirizine Impurity D (Dihydrochloride) is 856841-95-7. It is also known as Cetirizine Dimer Dihydrochloride, 1,4-Bis[(4-chlorophenyl)phenylmethyl]piperazine Dihydrochloride, USP Cetirizine Dimer Dihydrochloride.

What is the molecular formula and molecular weight of Cetirizine Impurity D (Dihydrochloride)?

Cetirizine Impurity D (Dihydrochloride) has the molecular formula C30H28Cl2N2 and a molecular weight of 487.5 g/mol. Its IUPAC name is 1,4-bis[(4-chlorophenyl)-phenylmethyl]piperazine.

What is Cetirizine Impurity D (Dihydrochloride) used for?

Cetirizine Impurity D (Dihydrochloride) is supplied as a characterised reference material related to Cetirizine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Cetirizine Impurity D (Dihydrochloride) can I order?

We supply Cetirizine Impurity D (Dihydrochloride) in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Cetirizine Impurity D (Dihydrochloride)?

Yes. Every lot of Cetirizine Impurity D (Dihydrochloride) is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Cetirizine Impurity D (Dihydrochloride) be shipped internationally?

Yes. Cetirizine Impurity D (Dihydrochloride) is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.