Pemetrexed EP Impurity A (Freebase)

Name: Pemetrexed EP Impurity A (Freebase)
Brand: Vaqora Chemicals
SKU: VQ-006575

About Pemetrexed EP Impurity A (Freebase)

Listed under CAS 869791-42-4, Pemetrexed EP Impurity A (Freebase) is a pharmacopeial impurity of Pemetrexed available from Vaqora Chemicals. The compound has the formula C21H23N5O6, corresponding to a molecular weight of 441.4 g/mol. The IUPAC name is (2S)-2-[[4-[2-(2-amino-1-methyl-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid. It is also known as N-Methyl Pemetrexed or Pemetrexed N-Methyl Analog.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

Pharmaceutical QC and development laboratories use this impurity standard of Pemetrexed to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Pemetrexed EP Impurity A (Freebase) is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Pemetrexed

View every impurity, metabolite and intermediate we list for Pemetrexed.

Pemetrexed impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Pemetrexed EP Impurity A (Freebase)
Catalogue No.	VQ-006575
CAS Number	869791-42-4
Other CAS	2243918-27-4
IUPAC name	(2S)-2-[[4-[2-(2-amino-1-methyl-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid
Molecular formula	C₂₁H₂₃N₅O₆
Molecular weight	441.4 g/mol
Exact mass	441.1648
Grade	Reference Standard
HSN code	38229090
InChIKey	JKULRGFPYBAJTE-AWEZNQCLSA-N
SMILES	CN1C2=C(C(=CN2)CCC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(=O)N=C1N
PubChem CID	91974867

Physical properties
Physical form	Solid
LogP (XLogP3)	0.4
H-bond donors / acceptors	5 / 6
TPSA	178 Å²

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H341Suspected of causing genetic defects
H360May damage fertility or the unborn child
H373May causes damage to organs through prolonged or repeated exposure

Precautionary statements: P203, P260, P264, P264 + P265, P280, P302 + P352, P305 + P351 + P338, P318, P319, P321, P332 + P317, P337 + P317, P362 + P364, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Pemetrexed EP Impurity A (Freebase)?

The CAS Registry Number of Pemetrexed EP Impurity A (Freebase) is 869791-42-4. It is also known as N-Methyl Pemetrexed, Pemetrexed N-Methyl Analog, Pemetrexed EP Impurity A.

What is the molecular formula and molecular weight of Pemetrexed EP Impurity A (Freebase)?

Pemetrexed EP Impurity A (Freebase) has the molecular formula C21H23N5O6 and a molecular weight of 441.4 g/mol. Its IUPAC name is (2S)-2-[[4-[2-(2-amino-1-methyl-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid.

What is Pemetrexed EP Impurity A (Freebase) used for?

Pemetrexed EP Impurity A (Freebase) is supplied as a characterised reference material related to Pemetrexed. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Pemetrexed EP Impurity A (Freebase) can I order?

We supply Pemetrexed EP Impurity A (Freebase) in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Pemetrexed EP Impurity A (Freebase)?

Yes. Every lot of Pemetrexed EP Impurity A (Freebase) is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Pemetrexed EP Impurity A (Freebase) be shipped internationally?

Yes. Pemetrexed EP Impurity A (Freebase) is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.