Bendamustine Ethyl Ester

About Bendamustine Ethyl Ester

Bendamustine Ethyl Ester is a process intermediate or related compound of Bendamustine carrying the CAS registry number 87475-54-5 at a purity of 98.95%. Its molecular formula is C18H25Cl2N3O2 and its molecular weight is 386.3 g/mol. Systematically, it is named ethyl 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoate. It is also known as Bendamustine USP RC I.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

Process chemists and analysts use it when developing synthetic routes to Bendamustine, tracking process-related impurities and validating analytical methods. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer Bendamustine Ethyl Ester in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide. Stock is available for quick dispatch.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Bendamustine

View every impurity, metabolite and intermediate we list for Bendamustine.

Bendamustine impurities

Specifications & identifiers

Chemical identifiers
Product name	Bendamustine Ethyl Ester
Catalogue No.	VQ-013206
CAS Number	87475-54-5
IUPAC name	ethyl 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoate
Molecular formula	C₁₈H₂₅Cl₂N₃O₂
Molecular weight	386.3 g/mol
Exact mass	385.1324
Grade	Reference Standard
Purity / assay	98.95%
HSN code	2933
InChIKey	GVLZDNWNOBSNEN-UHFFFAOYSA-N
SMILES	CCOC(=O)CCCC1=NC2=C(N1C)C=CC(=C2)N(CCCl)CCCl
PubChem CID	23238075

Physical properties
Physical form	Solid
LogP (XLogP3)	3.6
H-bond donors / acceptors	0 / 4
TPSA	47.4 Å²
Synonyms	4-[5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazol-2-yl]butyric acid ethyl ester, Ethyl 5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoate, Ethyl 4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate, Ethyl 5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzimidazole-2-butanoate, Ethyl 4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzimidazol-2-yl)butanoate, 1H-Benzimidazole-2-butanoic acid, 5-(bis(2-chloroethyl)amino)-1-methyl-, ethyl ester, 1H-Benzimidazole-2-butanoic acid,5-[bis(2-chloroethyl)amino]-1-methyl-, ethyl ester, Bendamustine USP RC I

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H315Causes skin irritation
H341Suspected of causing genetic defects
H351Suspected of causing cancer
H360May damage fertility or the unborn child

Precautionary statements: P203, P264, P270, P280, P301 + P316, P302 + P352, P318, P321, P330, P332 + P317, P362 + P364, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Bendamustine Ethyl Ester?

The CAS Registry Number of Bendamustine Ethyl Ester is 87475-54-5. It is also known as 4-[5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazol-2-yl]butyric acid ethyl ester, Ethyl 5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoate, Ethyl 4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate.

What is the molecular formula and molecular weight of Bendamustine Ethyl Ester?

Bendamustine Ethyl Ester has the molecular formula C18H25Cl2N3O2 and a molecular weight of 386.3 g/mol. Its IUPAC name is ethyl 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoate.

What is Bendamustine Ethyl Ester used for?

Bendamustine Ethyl Ester is supplied as a characterised reference material related to Bendamustine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Bendamustine Ethyl Ester can I order?

We supply Bendamustine Ethyl Ester in Reference Standard (98.95%) grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Bendamustine Ethyl Ester?

Yes. Every lot of Bendamustine Ethyl Ester is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Bendamustine Ethyl Ester be shipped internationally?

Yes. Bendamustine Ethyl Ester is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.