8-Chloro-5-nitroso-5,10-dihydro-11H-dibenzo[b… 90353-66-5

Name: 8-Chloro-5-nitroso-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one
Brand: Vaqora Chemicals
SKU: VQ-044695

About 8-Chloro-5-nitroso-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

Listed under CAS 90353-66-5, 8-Chloro-5-nitroso-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one is a nitrosamine impurity of Clozapine available from Vaqora Chemicals. Formula C13H8ClN3O2, molecular weight 273.67 g/mol. The IUPAC name is 3-chloro-11-nitroso-5H-benzo[b][1,4]benzodiazepin-6-one.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Good laboratory practice and suitable PPE are recommended during handling.

It is used as a reference standard for trace-level detection and quantitation of nitrosamine impurities by LC-MS/MS or GC-MS, supporting nitrosamine risk assessments for Clozapine, method validation (AMV) and regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Clozapine

View every impurity, metabolite and intermediate we list for Clozapine.

Clozapine impurities

Specifications & identifiers

Chemical identifiers
Product name	8-Chloro-5-nitroso-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one
Catalogue No.	VQ-044695
CAS Number	90353-66-5
IUPAC name	3-chloro-11-nitroso-5H-benzo[b][1,4]benzodiazepin-6-one
Molecular formula	C₁₃H₈ClN₃O₂
Molecular weight	273.67 g/mol
Exact mass	273.0305
Grade	Reference Standard
HSN code	38229090
InChIKey	WYCFOCJRCMOUNT-UHFFFAOYSA-N
SMILES	C1=CC=C2C(=C1)C(=O)NC3=C(N2N=O)C=CC(=C3)Cl
PubChem CID	13287909

Physical properties
Physical form	Solid
LogP (XLogP3)	2.8
H-bond donors / acceptors	1 / 4
TPSA	61.8 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 8-Chloro-5-nitroso-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one?

The CAS Registry Number of 8-Chloro-5-nitroso-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one is 90353-66-5. It is also known as 8-Chloro-5,10-dihydro-5-nitroso-11H-dibenzo[b,e][1,4]diazepin-11-one.

What is the molecular formula and molecular weight of 8-Chloro-5-nitroso-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one?

8-Chloro-5-nitroso-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one has the molecular formula C13H8ClN3O2 and a molecular weight of 273.67 g/mol. Its IUPAC name is 3-chloro-11-nitroso-5H-benzo[b][1,4]benzodiazepin-6-one.

What is 8-Chloro-5-nitroso-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one used for?

8-Chloro-5-nitroso-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one is supplied as a characterised reference material related to Clozapine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 8-Chloro-5-nitroso-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one can I order?

We supply 8-Chloro-5-nitroso-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 8-Chloro-5-nitroso-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one?

Yes. Every lot of 8-Chloro-5-nitroso-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 8-Chloro-5-nitroso-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one be shipped internationally?

Yes. We export 8-Chloro-5-nitroso-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.