4-(Difluoromethoxy)-3-Hydroxybenzoic Acid

Name: 4-(Difluoromethoxy)-3-Hydroxybenzoic Acid
Brand: Vaqora Chemicals
SKU: VQ-041982

About 4-(Difluoromethoxy)-3-Hydroxybenzoic Acid

4-(Difluoromethoxy)-3-Hydroxybenzoic Acid (CAS 913985-07-6) is a metabolite or degradation product of Roflumilast offered by Vaqora Chemicals. Formula C8H6F2O4, molecular weight 204.13 g/mol. Common synonyms include Benzoic acid, 4-(difluoromethoxy)-3-hydroxy-.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Analytical teams use this compound to identify metabolites and degradants of Roflumilast, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer 4-(Difluoromethoxy)-3-Hydroxybenzoic Acid in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Roflumilast

View every impurity, metabolite and intermediate we list for Roflumilast.

Roflumilast impurities

Specifications & identifiers

Chemical identifiers
Product name	4-(Difluoromethoxy)-3-Hydroxybenzoic Acid
Catalogue No.	VQ-041982
CAS Number	913985-07-6
IUPAC name	4-(difluoromethoxy)-3-hydroxybenzoic acid
Molecular formula	C₈H₆F₂O₄
Molecular weight	204.13 g/mol
Exact mass	204.0234
Grade	Reference Standard
HSN code	38229090
InChIKey	BWKXOOXYCKHVMK-UHFFFAOYSA-N
SMILES	C1=CC(=C(C=C1C(=O)O)O)OC(F)F
PubChem CID	59224129

Physical properties
Physical form	Solid
LogP (XLogP3)	2.4
H-bond donors / acceptors	2 / 6
TPSA	66.8 Å²

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4-(Difluoromethoxy)-3-Hydroxybenzoic Acid?

The CAS Registry Number of 4-(Difluoromethoxy)-3-Hydroxybenzoic Acid is 913985-07-6. It is also known as Benzoic acid, 4-(difluoromethoxy)-3-hydroxy-.

What is the molecular formula and molecular weight of 4-(Difluoromethoxy)-3-Hydroxybenzoic Acid?

4-(Difluoromethoxy)-3-Hydroxybenzoic Acid has the molecular formula C8H6F2O4 and a molecular weight of 204.13 g/mol. Its IUPAC name is 4-(difluoromethoxy)-3-hydroxybenzoic acid.

What is 4-(Difluoromethoxy)-3-Hydroxybenzoic Acid used for?

4-(Difluoromethoxy)-3-Hydroxybenzoic Acid is supplied as a characterised reference material related to Roflumilast. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4-(Difluoromethoxy)-3-Hydroxybenzoic Acid can I order?

We supply 4-(Difluoromethoxy)-3-Hydroxybenzoic Acid in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4-(Difluoromethoxy)-3-Hydroxybenzoic Acid?

Yes. Every lot of 4-(Difluoromethoxy)-3-Hydroxybenzoic Acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4-(Difluoromethoxy)-3-Hydroxybenzoic Acid be shipped internationally?

Yes. 4-(Difluoromethoxy)-3-Hydroxybenzoic Acid is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.