(R,S,S,S)-Nebivolol Hydrochloride

Name: (R,S,S,S)-Nebivolol Hydrochloride
Brand: Vaqora Chemicals
SKU: VQ-032083

About (R,S,S,S)-Nebivolol Hydrochloride

(R,S,S,S)-Nebivolol Hydrochloride (CAS 920299-33-8) is a high-purity reference standard of Nebivolol offered by Vaqora Chemicals. Formula C22H26ClF2NO4, molecular weight 441.9 g/mol. Alternative names: L-Nebivolol Hydrochloride and Nebivolol (S,R,S,S)-Isomer (HCl salt).

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Laboratories use this Nebivolol standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material
Fine chemical synthesis

Industries

Related to Nebivolol

View every impurity, metabolite and intermediate we list for Nebivolol.

Nebivolol impurities

Specifications & identifiers

Chemical identifiers
Product name	(R,S,S,S)-Nebivolol Hydrochloride
Catalogue No.	VQ-032083
CAS Number	920299-33-8
IUPAC name	(1S)-1-[(2R)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-[[(2S)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]amino]ethanol;hydrochloride
Molecular formula	C₂₂H₂₆ClF₂NO₄
Molecular weight	441.9 g/mol
Exact mass	441.1518
Grade	Reference Standard
HSN code	38229090
InChIKey	JWEXHQAEWHKGCW-BIISKSHESA-N
SMILES	C1CC2=C(C=CC(=C2)F)O[C@H]1[C@H](CNC[C@@H]([C@@H]3CCC4=C(O3)C=CC(=C4)F)O)O.Cl
PubChem CID	11626384

Physical properties
Physical form	Solid
H-bond donors / acceptors	4 / 7
TPSA	71 Å²
Synonyms	L-Nebivolol Hydrochloride, Nebivolol (S,R,S,S)-Isomer (HCl salt), rac Nebivolol hydrochloride, Nebivolol (hydrochloride), Nebivolol HCl - Bio-X trade mark, (R,S,S,S)-nebivolol monohydrochloride

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Environmental hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
H413May cause long lasting harmful effects to aquatic life

Precautionary statements: P203, P264, P270, P273, P280, P301 + P317, P318, P330, P391, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (R,S,S,S)-Nebivolol Hydrochloride?

The CAS Registry Number of (R,S,S,S)-Nebivolol Hydrochloride is 920299-33-8. It is also known as L-Nebivolol Hydrochloride, Nebivolol (S,R,S,S)-Isomer (HCl salt), rac Nebivolol hydrochloride.

What is the molecular formula and molecular weight of (R,S,S,S)-Nebivolol Hydrochloride?

(R,S,S,S)-Nebivolol Hydrochloride has the molecular formula C22H26ClF2NO4 and a molecular weight of 441.9 g/mol.

What is (R,S,S,S)-Nebivolol Hydrochloride used for?

(R,S,S,S)-Nebivolol Hydrochloride is supplied as a characterised reference material related to Nebivolol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (R,S,S,S)-Nebivolol Hydrochloride can I order?

We supply (R,S,S,S)-Nebivolol Hydrochloride in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (R,S,S,S)-Nebivolol Hydrochloride?

Yes. Every lot of (R,S,S,S)-Nebivolol Hydrochloride is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (R,S,S,S)-Nebivolol Hydrochloride be shipped internationally?

Yes. (R,S,S,S)-Nebivolol Hydrochloride is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.