Lumacaftor

Name: Lumacaftor
Brand: Vaqora Chemicals
SKU: VQ-026531

About Lumacaftor

Vaqora Chemicals supplies Lumacaftor, a high-purity reference standard of Lumacaftor registered under CAS number 936727-05-8. Its molecular formula is C24H18F2N2O5 and its molecular weight is 452.4 g/mol. Systematically, it is named 3-[6-[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid. Alternative names: VX-809 and VX 809.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

As a reference sample of Lumacaftor, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer Lumacaftor in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Lumacaftor

View every impurity, metabolite and intermediate we list for Lumacaftor.

Lumacaftor impurities

Specifications & identifiers

Chemical identifiers
Product name	Lumacaftor
Catalogue No.	VQ-026531
CAS Number	936727-05-8
IUPAC name	3-[6-[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid
Molecular formula	C₂₄H₁₈F₂N₂O₅
Molecular weight	452.4 g/mol
Exact mass	452.1184
Grade	Reference Standard
HSN code	38229090
InChIKey	UFSKUSARDNFIRC-UHFFFAOYSA-N
SMILES	CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O
PubChem CID	16678941

Physical properties
Physical form	Solid
LogP (XLogP3)	4.4
H-bond donors / acceptors	2 / 8
TPSA	97.8 Å²
Synonyms	VX-809, VX 809, VX-809 (Lumacaftor), Lumacaftor(vx-809vx809), Lumacaftor (USAN), Lumacaftor (VX-809), EX-A178

Safety & hazard information (GHS)

Corrosive

Toxic

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation
H360May damage fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements: P203, P260, P261, P264, P264 + P265, P270, P271, P280, P301 + P316, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P305 + P354 + P338, P317, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Lumacaftor?

The CAS Registry Number of Lumacaftor is 936727-05-8. It is also known as VX-809, VX 809, VX-809 (Lumacaftor).

What is the molecular formula and molecular weight of Lumacaftor?

Lumacaftor has the molecular formula C24H18F2N2O5 and a molecular weight of 452.4 g/mol. Its IUPAC name is 3-[6-[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid.

What is Lumacaftor used for?

Lumacaftor is supplied as a characterised reference material related to Lumacaftor. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Lumacaftor can I order?

We supply Lumacaftor in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Lumacaftor?

Yes. Every lot of Lumacaftor is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Lumacaftor be shipped internationally?

Yes. Lumacaftor is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.