Fosinopril EP Impurity A

About Fosinopril EP Impurity A

Fosinopril EP Impurity A is a pharmacopeial impurity of Fosinopril carrying the CAS registry number 95399-71-6. The compound has the formula C23H34NO5P, corresponding to a molecular weight of 435.5 g/mol. The IUPAC name is (2S,4S)-4-cyclohexyl-1-[2-[hydroxy(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid. It is also known as Fosinopril Sodium EP impurity A or Fosinopril Sodium - Impurity A.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Danger” with 1 hazard statement. Review the Safety Data Sheet before use.

Pharmaceutical QC and development laboratories use this impurity standard of Fosinopril to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Fosinopril

View every impurity, metabolite and intermediate we list for Fosinopril.

Fosinopril impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Fosinopril EP Impurity A
Catalogue No.	VQ-025921
CAS Number	95399-71-6
IUPAC name	(2S,4S)-4-cyclohexyl-1-[2-[hydroxy(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid
Molecular formula	C₂₃H₃₄NO₅P
Molecular weight	435.5 g/mol
Exact mass	435.2175
Grade	Reference Standard
HSN code	38229090
InChIKey	WOIWWYDXDVSWAZ-RTWAWAEBSA-N
SMILES	C1CCC(CC1)[C@@H]2C[C@H](N(C2)C(=O)CP(=O)(CCCCC3=CC=CC=C3)O)C(=O)O
PubChem CID	62956

Physical properties
Physical form	Solid
LogP (XLogP3)	3.8
H-bond donors / acceptors	2 / 5
TPSA	94.9 Å²
Synonyms	Fosinopril Sodium EP impurity A, Fosinopril Sodium - Impurity A, Fosinopril diacid, Fosinoprilic acid, (4S)-4-Cyclohexyl-1-((hydroxy(4-phenylbutyl)phosphinyl)acetyl)-L-proline, L-Proline, 4-cyclohexyl-1-((hydroxy(4-phenylbutyl)phosphinyl)acetyl)-, trans-, (4S)-4-cyclohexyl-1-{[hydroxy(4-phenylbutyl)phosphoryl]acetyl}-L-proline, (4S)-4-cyclohexyl-1-((hydroxy(4-phenylbutyl)phosphoryl)acetyl)-L-proline, L-Proline, 4-cyclohexyl-1-[[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-,(4S)-, (4S)-4-Cyclohexyl-[(4-phenylbutyl)phosphinyl]acetyl-L-proline, 1[{hydroxy(4-phenylbutyl)phosphinyl}acetyl]-(trans)-4-cyclohexyl-l-proline

Safety & hazard information (GHS)

Health hazard

Signal word: Danger

Hazard statements

H360May damage fertility or the unborn child

Precautionary statements: P203, P280, P318, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Fosinopril EP Impurity A?

The CAS Registry Number of Fosinopril EP Impurity A is 95399-71-6. It is also known as Fosinopril Sodium EP impurity A, Fosinopril Sodium - Impurity A, Fosinopril diacid.

What is the molecular formula and molecular weight of Fosinopril EP Impurity A?

Fosinopril EP Impurity A has the molecular formula C23H34NO5P and a molecular weight of 435.5 g/mol. Its IUPAC name is (2S,4S)-4-cyclohexyl-1-[2-[hydroxy(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid.

What is Fosinopril EP Impurity A used for?

Fosinopril EP Impurity A is supplied as a characterised reference material related to Fosinopril. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Fosinopril EP Impurity A can I order?

We supply Fosinopril EP Impurity A in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Fosinopril EP Impurity A?

Yes. Every lot of Fosinopril EP Impurity A is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Fosinopril EP Impurity A be shipped internationally?

Yes. Fosinopril EP Impurity A is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.