Betamethasone EP Impurity E

About Betamethasone EP Impurity E

Betamethasone EP Impurity E is a pharmacopeial impurity of Beclomethasone carrying the CAS registry number 981-34-0. The compound has the formula C22H28O5, corresponding to a molecular weight of 372.5 g/mol. Common synonyms include Betamethasone 9,11-Epoxide and Beclomethasone Dipropionate EP Impurity R.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

This Beclomethasone impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Betamethasone EP Impurity E is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Beclomethasone

View every impurity, metabolite and intermediate we list for Beclomethasone.

Beclomethasone impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Betamethasone EP Impurity E
Catalogue No.	VQ-021740
CAS Number	981-34-0
IUPAC name	(1S,2S,10S,11S,13S,14R,15S,17S)-14-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyl-18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadeca-3,6-dien-5-one
Molecular formula	C₂₂H₂₈O₅
Molecular weight	372.5 g/mol
Exact mass	372.1937
Grade	Reference Standard
HSN code	38229090
InChIKey	GBDXNHBVYAMODG-DEGNENOVSA-N
SMILES	C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]35[C@@H](O5)C[C@@]2([C@]1(C(=O)CO)O)C)C
PubChem CID	101933

Physical properties
Physical form	Solid
LogP (XLogP3)	2
H-bond donors / acceptors	2 / 5
TPSA	87.1 Å²
Synonyms	Betamethasone 9,11-Epoxide, Beclomethasone Dipropionate EP Impurity R, Beclometasone Dipropionate EP Impurity R, Beclomethasone Dipropionate - Impurity R, Betamethasone - Impurity E, 9,11beta-Epoxy-17,21-dihydroxy-16beta-methyl-9beta-pregna-1,4-diene-3,20-dione, Pregna-1,4-diene-3,20-dione, 9,11-epoxy-17,21-dihydroxy-16-methyl-, (9beta,11beta,16beta)-, 16-beta Methyl Epoxide, (9beta,11beta,16beta)-9,11-Epoxy-17,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9beta,11beta-Epoxy-17,21-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione, 9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione, 9b,11b-Epoxy-17,21-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Betamethasone EP Impurity E?

The CAS Registry Number of Betamethasone EP Impurity E is 981-34-0. It is also known as Betamethasone 9,11-Epoxide, Beclomethasone Dipropionate EP Impurity R, Beclometasone Dipropionate EP Impurity R.

What is the molecular formula and molecular weight of Betamethasone EP Impurity E?

Betamethasone EP Impurity E has the molecular formula C22H28O5 and a molecular weight of 372.5 g/mol. Its IUPAC name is (1S,2S,10S,11S,13S,14R,15S,17S)-14-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyl-18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadeca-3,6-dien-5-one.

What is Betamethasone EP Impurity E used for?

Betamethasone EP Impurity E is supplied as a characterised reference material related to Beclomethasone. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Betamethasone EP Impurity E can I order?

We supply Betamethasone EP Impurity E in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Betamethasone EP Impurity E?

Yes. Every lot of Betamethasone EP Impurity E is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Betamethasone EP Impurity E be shipped internationally?

Yes. We export Betamethasone EP Impurity E worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.