2-Keto Crizotinib

Name: 2-Keto Crizotinib
Brand: Vaqora Chemicals
SKU: VQ-022265

About 2-Keto Crizotinib

2-Keto Crizotinib is a metabolite or degradation product of Crizotinib carrying the CAS registry number 1415558-82-5. Its molecular formula is C21H20Cl2FN5O2 and its molecular weight is 464.3 g/mol. The IUPAC name is 4-[4-[6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-pyridinyl]pyrazol-1-yl]piperidin-2-one. It is also known as Crizotinib lactam metabolite (m10).

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Good laboratory practice and suitable PPE are recommended during handling.

Analytical teams use this compound to identify metabolites and degradants of Crizotinib, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies 2-Keto Crizotinib in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Crizotinib

View every impurity, metabolite and intermediate we list for Crizotinib.

Crizotinib impurities

Specifications & identifiers

Chemical identifiers
Product name	2-Keto Crizotinib
Catalogue No.	VQ-022265
CAS Number	1415558-82-5
IUPAC name	4-[4-[6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-pyridinyl]pyrazol-1-yl]piperidin-2-one
Molecular formula	C₂₁H₂₀Cl₂FN₅O₂
Molecular weight	464.3 g/mol
Exact mass	463.0978
Grade	Reference Standard
HSN code	38229090
InChIKey	KLXFBZLBBBMWAI-YNODCEANSA-N
SMILES	C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNC(=O)C4)N
PubChem CID	131668046

Physical properties
Physical form	Solid
LogP (XLogP3)	3
H-bond donors / acceptors	2 / 6
TPSA	95.1 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2-Keto Crizotinib?

The CAS Registry Number of 2-Keto Crizotinib is 1415558-82-5. It is also known as Crizotinib lactam metabolite (m10).

What is the molecular formula and molecular weight of 2-Keto Crizotinib?

2-Keto Crizotinib has the molecular formula C21H20Cl2FN5O2 and a molecular weight of 464.3 g/mol. Its IUPAC name is 4-[4-[6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-pyridinyl]pyrazol-1-yl]piperidin-2-one.

What is 2-Keto Crizotinib used for?

2-Keto Crizotinib is supplied as a characterised reference material related to Crizotinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2-Keto Crizotinib can I order?

We supply 2-Keto Crizotinib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2-Keto Crizotinib?

Yes. Every lot of 2-Keto Crizotinib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2-Keto Crizotinib be shipped internationally?

Yes. We export 2-Keto Crizotinib worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.