(S)-Crizotinib

Name: (S)-Crizotinib
Brand: Vaqora Chemicals
SKU: VQ-022264

About (S)-Crizotinib

Vaqora Chemicals supplies (S)-Crizotinib, a high-purity reference standard of Crizotinib registered under CAS number 1374356-45-2. The compound has the formula C21H22Cl2FN5O, corresponding to a molecular weight of 450.3 g/mol. Its systematic (IUPAC) name is 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine. It is also known as Crizotinib S-Isomer or ent-crizotinib.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Good laboratory practice and suitable PPE are recommended during handling.

Laboratories use this Crizotinib standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, (S)-Crizotinib is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Crizotinib

View every impurity, metabolite and intermediate we list for Crizotinib.

Crizotinib impurities

Specifications & identifiers

Chemical identifiers
Product name	(S)-Crizotinib
Catalogue No.	VQ-022264
CAS Number	1374356-45-2
IUPAC name	3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
Molecular formula	C₂₁H₂₂Cl₂FN₅O
Molecular weight	450.3 g/mol
Exact mass	449.1185
Grade	Reference Standard
HSN code	38229090
InChIKey	KTEIFNKAUNYNJU-LBPRGKRZSA-N
SMILES	C[C@@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
PubChem CID	56671814

Physical properties
Physical form	Solid
LogP (XLogP3)	3.7
H-bond donors / acceptors	2 / 6
TPSA	78 Å²
Synonyms	Crizotinib S-Isomer, ent-crizotinib, crizotinib-(S), Crizotinib, (S)-, (S)-crizotinibent-crizotinib, EX-A5639

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (S)-Crizotinib?

The CAS Registry Number of (S)-Crizotinib is 1374356-45-2. It is also known as Crizotinib S-Isomer, ent-crizotinib, crizotinib-(S).

What is the molecular formula and molecular weight of (S)-Crizotinib?

(S)-Crizotinib has the molecular formula C21H22Cl2FN5O and a molecular weight of 450.3 g/mol. Its IUPAC name is 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine.

What is (S)-Crizotinib used for?

(S)-Crizotinib is supplied as a characterised reference material related to Crizotinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (S)-Crizotinib can I order?

We supply (S)-Crizotinib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (S)-Crizotinib?

Yes. Every lot of (S)-Crizotinib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (S)-Crizotinib be shipped internationally?

Yes. We export (S)-Crizotinib worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.