3-Cyclopropylmethoxy-4- difluoromethoxy-benzo… 162401-62-9

Name: 3-Cyclopropylmethoxy-4- difluoromethoxy-benzoic acid
Brand: Vaqora Chemicals
SKU: VQ-027879

About 3-Cyclopropylmethoxy-4- difluoromethoxy-benzoic acid

Listed under CAS 162401-62-9, 3-Cyclopropylmethoxy-4- difluoromethoxy-benzoic acid is an impurity of Roflumilast available from Vaqora Chemicals. Its molecular formula is C12H12F2O4 and its molecular weight is 258.22 g/mol. Alternative names: Roflumilast intermediate B.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. It carries the GHS signal word “Danger” with 7 hazard statements. Review the Safety Data Sheet before use.

Pharmaceutical QC and development laboratories use this impurity standard of Roflumilast to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 3-Cyclopropylmethoxy-4- difluoromethoxy-benzoic acid is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Roflumilast

View every impurity, metabolite and intermediate we list for Roflumilast.

Roflumilast impurities

Specifications & identifiers

Chemical identifiers
Product name	3-Cyclopropylmethoxy-4- difluoromethoxy-benzoic acid
Catalogue No.	VQ-027879
CAS Number	162401-62-9
IUPAC name	3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid
Molecular formula	C₁₂H₁₂F₂O₄
Molecular weight	258.22 g/mol
Exact mass	258.0704
Grade	Reference Standard
HSN code	38229090
InChIKey	IGFDIFLMMLWKKY-UHFFFAOYSA-N
SMILES	C1CC1COC2=C(C=CC(=C2)C(=O)O)OC(F)F
PubChem CID	2394006

Physical properties
Physical form	Solid
LogP (XLogP3)	3.3
H-bond donors / acceptors	1 / 6
TPSA	55.8 Å²

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Environmental hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H411Toxic to aquatic life with long lasting effects
H413May cause long lasting harmful effects to aquatic life

Precautionary statements: P261, P264, P264 + P265, P270, P271, P273, P280, P301 + P316, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P391, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 3-Cyclopropylmethoxy-4- difluoromethoxy-benzoic acid?

The CAS Registry Number of 3-Cyclopropylmethoxy-4- difluoromethoxy-benzoic acid is 162401-62-9. It is also known as Benzoic acid, 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-, Roflumilast intermediate B.

What is the molecular formula and molecular weight of 3-Cyclopropylmethoxy-4- difluoromethoxy-benzoic acid?

3-Cyclopropylmethoxy-4- difluoromethoxy-benzoic acid has the molecular formula C12H12F2O4 and a molecular weight of 258.22 g/mol. Its IUPAC name is 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid.

What is 3-Cyclopropylmethoxy-4- difluoromethoxy-benzoic acid used for?

3-Cyclopropylmethoxy-4- difluoromethoxy-benzoic acid is supplied as a characterised reference material related to Roflumilast. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 3-Cyclopropylmethoxy-4- difluoromethoxy-benzoic acid can I order?

We supply 3-Cyclopropylmethoxy-4- difluoromethoxy-benzoic acid in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 3-Cyclopropylmethoxy-4- difluoromethoxy-benzoic acid?

Yes. Every lot of 3-Cyclopropylmethoxy-4- difluoromethoxy-benzoic acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 3-Cyclopropylmethoxy-4- difluoromethoxy-benzoic acid be shipped internationally?

Yes. 3-Cyclopropylmethoxy-4- difluoromethoxy-benzoic acid is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.