(3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-ol 156928-09-5

Name: (3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
Brand: Vaqora Chemicals
SKU: VQ-030068

About (3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-ol

(3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-ol (CAS 156928-09-5) is an impurity of Darunavir offered by Vaqora Chemicals. The compound has the formula C6H10O3, corresponding to a molecular weight of 130.14 g/mol. The IUPAC name is (3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-ol. Alternative names: EX-A3272 and 3-Hydroxy-(3R,3|AS,6|AR)-bis-tetrahydrofuran.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

As a characterised impurity of Darunavir, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, (3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-ol is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Darunavir

View every impurity, metabolite and intermediate we list for Darunavir.

Darunavir impurities

Specifications & identifiers

Chemical identifiers
Product name	(3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
Catalogue No.	VQ-030068
CAS Number	156928-09-5
IUPAC name	(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-ol
Molecular formula	C₆H₁₀O₃
Molecular weight	130.14 g/mol
Exact mass	130.063
Grade	Reference Standard
HSN code	38229090
InChIKey	RCDXYCHYMULCDZ-HCWXCVPCSA-N
SMILES	C1CO[C@H]2[C@@H]1[C@H](CO2)O
PubChem CID	9942150

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.4
H-bond donors / acceptors	1 / 3
TPSA	38.7 Å²
Synonyms	Furo[2,3-b]furan-3-ol, hexahydro-, (3R,3aS,6aR)-, rel-(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol, EX-A3272, 3-Hydroxy-(3R,3, AS,6, AR)-bis-tetrahydrofuran, (3R,3aS,6aR) 3-hydroxyhexahydrofuro[2,3-b]furan, (3R,3aS,6aR)-3-Hydroxyhexahydrofuro[2,3-b]furan, Furo[2,3-b]furan-3-ol,hexahydro-,(3R,3aS,6aR)-rel, (3R, 3aS, 6aR)-3-hydroxy-4H-hexahydrofuro[2,3-b]furan

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements: P260, P264, P270, P301 + P317, P319, P330, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-ol?

The CAS Registry Number of (3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-ol is 156928-09-5. It is also known as Furo[2,3-b]furan-3-ol, hexahydro-, (3R,3aS,6aR)-, rel-(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol, EX-A3272.

What is the molecular formula and molecular weight of (3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-ol?

(3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-ol has the molecular formula C6H10O3 and a molecular weight of 130.14 g/mol. Its IUPAC name is (3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-ol.

What is (3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-ol used for?

(3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-ol is supplied as a characterised reference material related to Darunavir. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-ol can I order?

We supply (3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-ol in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-ol?

Yes. Every lot of (3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-ol is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-ol be shipped internationally?

Yes. (3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-ol is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.