Darunavir

Name: Darunavir
Brand: Vaqora Chemicals
SKU: VQ-030065

About Darunavir

Vaqora Chemicals supplies Darunavir, a high-purity reference standard of Darunavir registered under CAS number 206361-99-1. Its molecular formula is C27H37N3O7S and its molecular weight is 547.7 g/mol. Alternative names: TMC-114 and TMC 114.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Laboratories use this Darunavir standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Darunavir in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Darunavir

View every impurity, metabolite and intermediate we list for Darunavir.

Darunavir impurities

Specifications & identifiers

Chemical identifiers
Product name	Darunavir
Catalogue No.	VQ-030065
CAS Number	206361-99-1
IUPAC name	[(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate
Molecular formula	C₂₇H₃₇N₃O₇S
Molecular weight	547.7 g/mol
Exact mass	547.2352
Grade	Reference Standard
HSN code	38229090
InChIKey	CJBJHOAVZSMMDJ-HEXNFIEUSA-N
SMILES	CC(C)CN(C[C@H]([C@H](CC1=CC=CC=C1)NC(=O)O[C@H]2CO[C@@H]3[C@H]2CCO3)O)S(=O)(=O)C4=CC=C(C=C4)N
PubChem CID	213039

Physical properties
Physical form	Solid
LogP (XLogP3)	2.9
H-bond donors / acceptors	3 / 9
TPSA	149 Å²
Synonyms	TMC-114, TMC 114, Ethanolate, Darunavir, 114, TMC, 2ien, 2f8g, 4ll3, Prezista(TM), 2idw, 3bvb, 3cyw, 3ekt

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P272, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P333 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Darunavir?

The CAS Registry Number of Darunavir is 206361-99-1. It is also known as TMC-114, TMC 114, Ethanolate, Darunavir.

What is the molecular formula and molecular weight of Darunavir?

Darunavir has the molecular formula C27H37N3O7S and a molecular weight of 547.7 g/mol. Its IUPAC name is [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate.

What is Darunavir used for?

Darunavir is supplied as a characterised reference material related to Darunavir. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Darunavir can I order?

We supply Darunavir in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Darunavir?

Yes. Every lot of Darunavir is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Darunavir be shipped internationally?

Yes. Darunavir is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.