Impurity reference standards
Darunavir impurities & reference standards
Characterised Darunavir impurities, degradation products and related compounds for analytical method development, validation, QC release and regulatory filings.
47reference materials
1isotope-labelled
COAHPLC · NMR · MS on request
![(3AR,4R,6aS)-4-Methoxytetrahydrofuro[3,4-b]furan-2(3H)-one chemical structure](/media/structures/LQEIOPTZKCKTPQ-WYDQCIBASA-N.svg)
(3AR,4R,6aS)-4-Methoxytetrahydrofuro[3,4-b]furan-2(3H)-one
- CAS
- 1932330-83-0
- Formula
- C7H10O4
- MW
- 158.15 g/mol
VQ-025205
![(3AR,4S,6aS)-4-Methoxytetrahydrofuro[3,4-b]furan-2(3H)-one chemical structure](/media/structures/LQEIOPTZKCKTPQ-XAHCXIQSSA-N.svg)
(3AR,4S,6aS)-4-Methoxytetrahydrofuro[3,4-b]furan-2(3H)-one
- CAS
- 1932353-11-1
- Formula
- C7H10O4
- MW
- 158.15 g/mol
VQ-030073
![(3AS,4R,6aR)-Tetrahydro-4-methoxyfuro[3,4-b]furan-2(3H)-one chemical structure](/media/structures/LQEIOPTZKCKTPQ-KZLJYQGOSA-N.svg)
(3AS,4R,6aR)-Tetrahydro-4-methoxyfuro[3,4-b]furan-2(3H)-one
- CAS
- 866594-61-8
- Formula
- C7H10O4
- MW
- 158.15 g/mol
VQ-025204
![(3AS,4S,6aR)-Tetrahydro-4-methoxyfuro[3,4-b]furan-2(3H)-one chemical structure](/media/structures/LQEIOPTZKCKTPQ-VPLCAKHXSA-N.svg)
(3AS,4S,6aR)-Tetrahydro-4-methoxyfuro[3,4-b]furan-2(3H)-one
- CAS
- 866594-60-7
- Formula
- C7H10O4
- MW
- 158.15 g/mol
VQ-030075
![(3R,3AR,6aS)-Hexahydrofuro[2,3-b]furan-3-yl 4-Nitrophenyl Ester Carbonic Acid chemical structure](/media/structures/ULTSJNOQNKVDBM-WOPDTQHZSA-N.svg)
(3R,3AR,6aS)-Hexahydrofuro[2,3-b]furan-3-yl 4-Nitrophenyl Ester Carbonic Acid
- CAS
- 252873-51-1
- Formula
- C13H13NO7
- MW
- 295.24 g/mol
VQ-036575
![(3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-ol chemical structure](/media/structures/RCDXYCHYMULCDZ-HCWXCVPCSA-N.svg)
![(3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-yl 4-nitrophenyl carbonate chemical structure](/media/structures/ULTSJNOQNKVDBM-SDDRHHMPSA-N.svg)
(3R,3AS,6aR)-hexahydrofuro[2,3-b]furan-3-yl 4-nitrophenyl carbonate
- CAS
- 192725-55-6
- Formula
- C13H13NO7
- MW
- 295.24 g/mol
VQ-025208
![(3S,3AR,6aS)-Hexahydrofuro[2,3-b]furan-3-yl 4-Nitrophenyl Ester Carbonic Acid chemical structure](/media/structures/ULTSJNOQNKVDBM-UTUOFQBUSA-N.svg)
(3S,3AR,6aS)-Hexahydrofuro[2,3-b]furan-3-yl 4-Nitrophenyl Ester Carbonic Acid
- CAS
- 288296-64-0
- Formula
- C13H13NO7
- MW
- 295.24 g/mol
VQ-036572
![(3S,3AR,6aS)-Hexahydrofuro[2,3-b]furan-3-ylcarbonyl Darunavir](/media/pack/3s3ar6as-hexahydrofuro23-bfuran-3-ylcarbonyl-darunavir.svg?v=3)
(3S,3AR,6aS)-Hexahydrofuro[2,3-b]furan-3-ylcarbonyl Darunavir
- CAS
- 1546918-97-1
- Formula
- C34H45N3O11S
- MW
- 703.8 g/mol
VQ-030077
![(3S,3AS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl 4-Nitrophenyl Ester Carbonic Acid chemical structure](/media/structures/ULTSJNOQNKVDBM-QJPTWQEYSA-N.svg)
(3S,3AS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl 4-Nitrophenyl Ester Carbonic Acid
- CAS
- 252873-01-1
- Formula
- C13H13NO7
- MW
- 295.24 g/mol
VQ-036576
![[(1S,2R)-1-Benzyl-2-hydroxy-3-[isobutyl-[(4-aminophenyl)sulfonyl]amino] propyl]carbamic Acid tert-Butyl Ester chemical structure](/media/structures/GSFKNEPGHWUCQO-XZOQPEGZSA-N.svg)
[(1S,2R)-1-Benzyl-2-hydroxy-3-[isobutyl-[(4-aminophenyl)sulfonyl]amino] propyl]carbamic Acid tert-Butyl Ester
- CAS
- 183004-94-6
- Formula
- C25H37N3O5S
- MW
- 491.6 g/mol
VQ-036573
![[(1S,2R)-1-Benzyl-2-hydroxy-3-[isobutyl[(4-nitro-phenyl)sulfonyl)]amino]propyl]-carbamic Acid tert-Butyl Ester chemical structure](/media/structures/CQGKCZKCWMWXQP-XZOQPEGZSA-N.svg)
[(1S,2R)-1-Benzyl-2-hydroxy-3-[isobutyl[(4-nitro-phenyl)sulfonyl)]amino]propyl]-carbamic Acid tert-Butyl Ester
- CAS
- 191226-98-9
- Formula
- C25H35N3O7S
- MW
- 521.6 g/mol
VQ-030079
amino]-2-hydroxy-1-(phenylmethyl)propyl]-Carbamic Acid Phenylmethyl Ester chemical structure](/media/structures/CLVKOWDYQHARFT-QBHOUYDASA-N.svg)
[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-Carbamic Acid Phenylmethyl Ester
- CAS
- 159005-61-5
- Formula
- C28H35N3O5S
- MW
- 525.7 g/mol
VQ-030066
![[(3R,3AS,6aR)-Hydroxyhexahydrofuro[2,3-b]furanyl Succinimidyl Carbonate chemical structure](/media/structures/VCFNCYVHQSHFRH-MHYGZLNHSA-N.svg)
[(3R,3AS,6aR)-Hydroxyhexahydrofuro[2,3-b]furanyl Succinimidyl Carbonate
- CAS
- 253265-97-3
- Formula
- C11H13NO7
- MW
- 271.22 g/mol
VQ-036567
![2,5-Dioxopyrrolidin-1-yl ((3S,3aR,6aS)-hexahydrofuro[2,3-b]furan-3-yl) carbonate chemical structure](/media/structures/VCFNCYVHQSHFRH-XSSZXYGBSA-N.svg)
2,5-Dioxopyrrolidin-1-yl ((3S,3aR,6aS)-hexahydrofuro[2,3-b]furan-3-yl) carbonate
- CAS
- 253265-98-4
- Formula
- C11H13NO7
- MW
- 271.22 g/mol
VQ-030069
4-Amino-N-(((4S,5R)-4-benzyl-2-oxooxazolidin-5-yl)methyl)-N-isobutylbenzenesulfonamide
- CAS
- 1418639-27-6
- Formula
- C21H27N3O4S
- MW
- 417.5 g/mol
VQ-025201
4-Amino-N-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide
- CAS
- 192800-79-6
- Formula
- C20H29N3O3S
- MW
- 391.5 g/mol
VQ-025203
Benzyl ((2S,3R)-3-Hydroxy-4-(isobutylamino)-1-phenylbutan-2-yl)carbamate
- CAS
- 143224-62-8
- Formula
- C22H30N2O3
- MW
- 370.5 g/mol
VQ-030078
N-(4-(N-((2R,3S)-3-Amino-2-hydroxy-4-phenylbutyl)-N-isobutylsulfamoyl)phenyl)acetamide
- CAS
- 157567-05-0
- Formula
- C22H31N3O4S
- MW
- 433.6 g/mol
VQ-043908
![N-[(1R,2S)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamic Acid 1,1-Dimethylethyl Ester chemical structure](/media/structures/CQGKCZKCWMWXQP-PKTZIBPZSA-N.svg)
N-[(1R,2S)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamic Acid 1,1-Dimethylethyl Ester
- CAS
- 1005324-46-8
- Formula
- C25H35N3O7S
- MW
- 521.6 g/mol
VQ-047959
Tert-Butyl ((2S,3R)-4-(4-acetamido-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
- CAS
- 160230-47-7
- Formula
- C27H39N3O6S
- MW
- 533.7 g/mol
VQ-025206
Tert-Butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl) carbamate
- CAS
- 165727-45-7
- Formula
- C15H22ClNO3
- MW
- 299.79 g/mol
VQ-039388
![Tert-Butyl [(1S,2R)-1-Benzyl-2-hydroxy-3-(isobutylamino)propyl]carbamate chemical structure](/media/structures/NVEPLQDORJSXRO-DLBZAZTESA-N.svg)
Tert-Butyl [(1S,2R)-1-Benzyl-2-hydroxy-3-(isobutylamino)propyl]carbamate
- CAS
- 160232-08-6
- Formula
- C19H32N2O3
- MW
- 336.5 g/mol
VQ-039590
FAQs — Darunavir impurities
Which Darunavir impurities do you supply?
We list 47 Darunavir-related reference materials, including process impurities, degradation products, stable-isotope-labelled standards and related compounds. Each is supplied with a COA, and characterisation data (HPLC, 1H-NMR, MS, IR) can be provided on request.
What are Darunavir impurity standards used for?
They are used for analytical method development and validation, impurity identification and quantification, forced-degradation and stability studies, and to support ANDA, DMF and other regulatory submissions under ICH Q3A/Q3B (and ICH M7 for mutagenic impurities).
Can you synthesise a Darunavir impurity that is not listed?
Yes. Our custom synthesis service can prepare and characterise unlisted impurities, metabolites and labelled analogues from milligram to gram scale. Share the structure or name and required quantity for a quotation.
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