4-Hydroxy Midazolam

Name: 4-Hydroxy Midazolam
Brand: Vaqora Chemicals
SKU: VQ-044840

About 4-Hydroxy Midazolam

Vaqora Chemicals supplies 4-Hydroxy Midazolam, a metabolite or degradation product of Midazolam registered under CAS number 59468-85-8. The compound has the formula C18H13ClFN3O, corresponding to a molecular weight of 341.8 g/mol. Its systematic (IUPAC) name is 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol. It is also known as 4-OH-Mdz or 4-OH midazolam.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Danger” with 1 hazard statement. Review the Safety Data Sheet before use.

Analytical teams use this compound to identify metabolites and degradants of Midazolam, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Midazolam

View every impurity, metabolite and intermediate we list for Midazolam.

Midazolam impurities

Specifications & identifiers

Chemical identifiers
Product name	4-Hydroxy Midazolam
Catalogue No.	VQ-044840
CAS Number	59468-85-8
IUPAC name	8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol
Molecular formula	C₁₈H₁₃ClFN₃O
Molecular weight	341.8 g/mol
Exact mass	341.0731
Grade	Reference Standard
HSN code	38229090
InChIKey	ZYISITHKPKHPKG-UHFFFAOYSA-N
SMILES	CC1=NC=C2N1C3=C(C=C(C=C3)Cl)C(=NC2O)C4=CC=CC=C4F
PubChem CID	124449

Physical properties
Physical form	Solid
LogP (XLogP3)	3.4
H-bond donors / acceptors	1 / 4
TPSA	50.4 Å²
Synonyms	4-OH-Mdz, 4H-Imidazo(1,5-a)(1,4)benzodiazepin-4-ol, 8-chloro-6-(2-fluorophenyl)-1-methyl-, 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-4-ol, 4-OH midazolam, 4H-Imidazo[1,5-a][1,4]benzodiazepin-4-ol,8-chloro-6-(2-fluorophenyl)-1-methyl-

Safety & hazard information (GHS)

Toxic

Signal word: Danger

Hazard statements

H301Toxic if swallowed

Precautionary statements: P264, P270, P301 + P316, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4-Hydroxy Midazolam?

The CAS Registry Number of 4-Hydroxy Midazolam is 59468-85-8. It is also known as 4-OH-Mdz, 4H-Imidazo(1,5-a)(1,4)benzodiazepin-4-ol, 8-chloro-6-(2-fluorophenyl)-1-methyl-, 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-4-ol.

What is the molecular formula and molecular weight of 4-Hydroxy Midazolam?

4-Hydroxy Midazolam has the molecular formula C18H13ClFN3O and a molecular weight of 341.8 g/mol. Its IUPAC name is 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol.

What is 4-Hydroxy Midazolam used for?

4-Hydroxy Midazolam is supplied as a characterised reference material related to Midazolam. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4-Hydroxy Midazolam can I order?

We supply 4-Hydroxy Midazolam in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4-Hydroxy Midazolam?

Yes. Every lot of 4-Hydroxy Midazolam is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4-Hydroxy Midazolam be shipped internationally?

Yes. 4-Hydroxy Midazolam is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.