4-Hydroxymethyl ambrisentan

Name: 4-Hydroxymethyl ambrisentan
Brand: Vaqora Chemicals
SKU: VQ-020782

About 4-Hydroxymethyl ambrisentan

4-Hydroxymethyl ambrisentan is a metabolite or degradation product of Ambrisentan carrying the CAS registry number 1106685-84-0. The compound has the formula C22H22N2O5, corresponding to a molecular weight of 394.4 g/mol. Its systematic (IUPAC) name is 2-[4-(hydroxymethyl)-6-methylpyrimidin-2-yl]oxy-3-methoxy-3,3-diphenylpropanoic acid. Common synonyms include Ambrisentan 4-Hydroxymethyl Analog Racemate and rac 4-Hydroxymethyl Ambrisentan.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Analytical teams use this compound to identify metabolites and degradants of Ambrisentan, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 4-Hydroxymethyl ambrisentan is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Ambrisentan

View every impurity, metabolite and intermediate we list for Ambrisentan.

Ambrisentan impurities

Specifications & identifiers

Chemical identifiers
Product name	4-Hydroxymethyl ambrisentan
Catalogue No.	VQ-020782
CAS Number	1106685-84-0
IUPAC name	2-[4-(hydroxymethyl)-6-methylpyrimidin-2-yl]oxy-3-methoxy-3,3-diphenylpropanoic acid
Molecular formula	C₂₂H₂₂N₂O₅
Molecular weight	394.4 g/mol
Exact mass	394.1529
Grade	Reference Standard
HSN code	38229090
InChIKey	PDUAYPFMBRYSNN-UHFFFAOYSA-N
SMILES	CC1=CC(=NC(=N1)OC(C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)CO
PubChem CID	25183520

Physical properties
Physical form	Solid
LogP (XLogP3)	2.6
H-bond donors / acceptors	2 / 7
TPSA	102 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4-Hydroxymethyl ambrisentan?

The CAS Registry Number of 4-Hydroxymethyl ambrisentan is 1106685-84-0. It is also known as Ambrisentan 4-Hydroxymethyl Analog Racemate, rac 4-Hydroxymethyl Ambrisentan, (S)-4-Hydroxymethyl Ambrisentan.

What is the molecular formula and molecular weight of 4-Hydroxymethyl ambrisentan?

4-Hydroxymethyl ambrisentan has the molecular formula C22H22N2O5 and a molecular weight of 394.4 g/mol. Its IUPAC name is 2-[4-(hydroxymethyl)-6-methylpyrimidin-2-yl]oxy-3-methoxy-3,3-diphenylpropanoic acid.

What is 4-Hydroxymethyl ambrisentan used for?

4-Hydroxymethyl ambrisentan is supplied as a characterised reference material related to Ambrisentan. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4-Hydroxymethyl ambrisentan can I order?

We supply 4-Hydroxymethyl ambrisentan in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4-Hydroxymethyl ambrisentan?

Yes. Every lot of 4-Hydroxymethyl ambrisentan is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4-Hydroxymethyl ambrisentan be shipped internationally?

Yes. We export 4-Hydroxymethyl ambrisentan worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.