(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic… 178306-52-0

Name: (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid
Brand: Vaqora Chemicals
SKU: VQ-020780

About (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid

(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid (CAS 178306-52-0) is an impurity of Ambrisentan offered by Vaqora Chemicals. Formula C16H16O4, molecular weight 272.29 g/mol. Its systematic (IUPAC) name is (2S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid. Common synonyms include (S)-2-Hydroxy-3-methoxy-3,3-diphenylprop.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Ambrisentan to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Ambrisentan

View every impurity, metabolite and intermediate we list for Ambrisentan.

Ambrisentan impurities

Specifications & identifiers

Chemical identifiers
Product name	(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid
Catalogue No.	VQ-020780
CAS Number	178306-52-0
IUPAC name	(2S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid
Molecular formula	C₁₆H₁₆O₄
Molecular weight	272.29 g/mol
Exact mass	272.1049
Grade	Reference Standard
HSN code	38229090
InChIKey	RQJWOLFMWKZKCJ-CQSZACIVSA-N
SMILES	COC(C1=CC=CC=C1)(C2=CC=CC=C2)[C@@H](C(=O)O)O
PubChem CID	15380898

Physical properties
Physical form	Solid
LogP (XLogP3)	2
H-bond donors / acceptors	2 / 4
TPSA	66.8 Å²
Synonyms	(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid, Benzenepropanoic acid, alpha-hydroxy-beta-methoxy-beta-phenyl-, (alphaS)-, (s)-2-hydroxy-3-methoxy-3,3-diphenyl propionic acid, (2S)-2-hydroxy-3-methoxy-3,3-diphenyl-propanoic acid, (S)-2-Hydroxy-3-methoxy-3,3-diphenylprop, Benzenepropanoic acid,, A-hydroxy-, A-methoxy-, A-phenyl-, (, AS)-

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation

Precautionary statements: P264, P264 + P265, P280, P302 + P352, P305 + P351 + P338, P321, P332 + P317, P337 + P317, P362 + P364

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid?

The CAS Registry Number of (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid is 178306-52-0. It is also known as (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid, Benzenepropanoic acid, alpha-hydroxy-beta-methoxy-beta-phenyl-, (alphaS)-, (s)-2-hydroxy-3-methoxy-3,3-diphenyl propionic acid.

What is the molecular formula and molecular weight of (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid?

(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid has the molecular formula C16H16O4 and a molecular weight of 272.29 g/mol. Its IUPAC name is (2S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid.

What is (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid used for?

(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid is supplied as a characterised reference material related to Ambrisentan. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid can I order?

We supply (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid?

Yes. Every lot of (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid be shipped internationally?

Yes. (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.