4,6-Dichloro-5-(4-chlorophenyl)pyrimidine

Name: 4,6-Dichloro-5-(4-chlorophenyl)pyrimidine
Brand: Vaqora Chemicals
SKU: VQ-031709

About 4,6-Dichloro-5-(4-chlorophenyl)pyrimidine

Listed under CAS 3974-18-3, 4,6-Dichloro-5-(4-chlorophenyl)pyrimidine is an impurity of Macitentan available from Vaqora Chemicals. Formula C10H5Cl3N2, molecular weight 259.5 g/mol. Alternative names: Pyrimidine, 4,6-dichloro-5-(4-chlorophenyl)- and 5-(4-Chlorophenyl)-4,6-dichloropyrimidine.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

This Macitentan impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 4,6-Dichloro-5-(4-chlorophenyl)pyrimidine is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Macitentan

View every impurity, metabolite and intermediate we list for Macitentan.

Macitentan impurities

Specifications & identifiers

Chemical identifiers
Product name	4,6-Dichloro-5-(4-chlorophenyl)pyrimidine
Catalogue No.	VQ-031709
CAS Number	3974-18-3
IUPAC name	4,6-dichloro-5-(4-chlorophenyl)pyrimidine
Molecular formula	C₁₀H₅Cl₃N₂
Molecular weight	259.5 g/mol
Exact mass	257.9518
Grade	Reference Standard
HSN code	38229090
InChIKey	KIYDKTUDEIWLNO-UHFFFAOYSA-N
SMILES	C1=CC(=CC=C1C2=C(N=CN=C2Cl)Cl)Cl
PubChem CID	21979569

Physical properties
Physical form	Solid
LogP (XLogP3)	4.4
H-bond donors / acceptors	0 / 2
TPSA	25.8 Å²

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation

Precautionary statements: P261, P264, P264 + P265, P272, P280, P302 + P352, P305 + P351 + P338, P321, P332 + P317, P333 + P317, P337 + P317, P362 + P364, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4,6-Dichloro-5-(4-chlorophenyl)pyrimidine?

The CAS Registry Number of 4,6-Dichloro-5-(4-chlorophenyl)pyrimidine is 3974-18-3. It is also known as Pyrimidine, 4,6-dichloro-5-(4-chlorophenyl)-, 5-(4-Chlorophenyl)-4,6-dichloropyrimidine.

What is the molecular formula and molecular weight of 4,6-Dichloro-5-(4-chlorophenyl)pyrimidine?

4,6-Dichloro-5-(4-chlorophenyl)pyrimidine has the molecular formula C10H5Cl3N2 and a molecular weight of 259.5 g/mol. Its IUPAC name is 4,6-dichloro-5-(4-chlorophenyl)pyrimidine.

What is 4,6-Dichloro-5-(4-chlorophenyl)pyrimidine used for?

4,6-Dichloro-5-(4-chlorophenyl)pyrimidine is supplied as a characterised reference material related to Macitentan. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4,6-Dichloro-5-(4-chlorophenyl)pyrimidine can I order?

We supply 4,6-Dichloro-5-(4-chlorophenyl)pyrimidine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4,6-Dichloro-5-(4-chlorophenyl)pyrimidine?

Yes. Every lot of 4,6-Dichloro-5-(4-chlorophenyl)pyrimidine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4,6-Dichloro-5-(4-chlorophenyl)pyrimidine be shipped internationally?

Yes. 4,6-Dichloro-5-(4-chlorophenyl)pyrimidine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.