5-O-Desmethyl Donepezil

Name: 5-O-Desmethyl Donepezil
Brand: Vaqora Chemicals
SKU: VQ-025368

About 5-O-Desmethyl Donepezil

Listed under CAS 120013-57-2, 5-O-Desmethyl Donepezil is a metabolite or degradation product of Donepezil available from Vaqora Chemicals. The compound has the formula C23H27NO3, corresponding to a molecular weight of 365.5 g/mol. The IUPAC name is 2-[(1-benzylpiperidin-4-yl)methyl]-5-hydroxy-6-methoxy-2,3-dihydroinden-1-one. Common synonyms include Donepezil (m2) and Donepezil (metabolite m2).

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Donepezil, as well as in QC testing and ANDA/DMF documentation. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 5-O-Desmethyl Donepezil is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Donepezil

View every impurity, metabolite and intermediate we list for Donepezil.

Donepezil impurities

Specifications & identifiers

Chemical identifiers
Product name	5-O-Desmethyl Donepezil
Catalogue No.	VQ-025368
CAS Number	120013-57-2
IUPAC name	2-[(1-benzylpiperidin-4-yl)methyl]-5-hydroxy-6-methoxy-2,3-dihydroinden-1-one
Molecular formula	C₂₃H₂₇NO₃
Molecular weight	365.5 g/mol
Exact mass	365.1991
Grade	Reference Standard
HSN code	38229090
InChIKey	DSMISVLYMKJMLP-UHFFFAOYSA-N
SMILES	COC1=C(C=C2CC(C(=O)C2=C1)CC3CCN(CC3)CC4=CC=CC=C4)O
PubChem CID	11503234

Physical properties
Physical form	Solid
LogP (XLogP3)	3.9
H-bond donors / acceptors	1 / 4
TPSA	49.8 Å²
Synonyms	Donepezil (m2), Donepezil (metabolite m2), 1-Benzyl-4-((5-hydroxy-6-methoxy-1-oxo-indan-2-yl)methyl)piperidine, 2-[(1-benzylpiperidin-4-yl)methyl]-5-hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one, 2-(1-benzylpiperidine-4-ylmethyl)-5-hydroxy-6-methoxyindan-1-one, 2-[(1-Benzyl-4-piperidinyl)methyl]-5-hydroxy-6-methoxyindan-1-one, 2-((1-benzylpiperidin-4-yl)methyl)-5-hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one, 1-benzyl-4-(5-hydroxy-6-methoxy-1-oxo-indan-2-yl)methylpiperidine, 2-((1-benzyl-4-piperidinyl)methyl)-5-hydroxy-6-methoxyindan-1-one, 2-((1-benzylpiperidin-4-yl)methyl)-5-hydroxy-6-methoxy-2,3-dihydroinden-1-one, 2-[(1-Benzyl-4-piperidinyl)methyl]-5-hydroxy-6-methoxy-1-indanone

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 5-O-Desmethyl Donepezil?

The CAS Registry Number of 5-O-Desmethyl Donepezil is 120013-57-2. It is also known as Donepezil (m2), Donepezil (metabolite m2), 1-Benzyl-4-((5-hydroxy-6-methoxy-1-oxo-indan-2-yl)methyl)piperidine.

What is the molecular formula and molecular weight of 5-O-Desmethyl Donepezil?

5-O-Desmethyl Donepezil has the molecular formula C23H27NO3 and a molecular weight of 365.5 g/mol. Its IUPAC name is 2-[(1-benzylpiperidin-4-yl)methyl]-5-hydroxy-6-methoxy-2,3-dihydroinden-1-one.

What is 5-O-Desmethyl Donepezil used for?

5-O-Desmethyl Donepezil is supplied as a characterised reference material related to Donepezil. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 5-O-Desmethyl Donepezil can I order?

We supply 5-O-Desmethyl Donepezil in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 5-O-Desmethyl Donepezil?

Yes. Every lot of 5-O-Desmethyl Donepezil is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 5-O-Desmethyl Donepezil be shipped internationally?

Yes. We export 5-O-Desmethyl Donepezil worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.