Donepezil EP Impurity F

Name: Donepezil EP Impurity F
Brand: Vaqora Chemicals
SKU: VQ-025372

About Donepezil EP Impurity F

Listed under CAS 145546-80-1, Donepezil EP Impurity F is a pharmacopeial impurity of Donepezil available from Vaqora Chemicals. Its molecular formula is C24H27NO3 and its molecular weight is 377.5 g/mol. Its systematic (IUPAC) name is (2E)-2-[(1-benzylpiperidin-4-yl)methylidene]-5,6-dimethoxy-3H-inden-1-one. Alternative names: (2E)-Dehydrodonepezil and Donepezil - Impurity F.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

This Donepezil impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Donepezil EP Impurity F in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Donepezil

View every impurity, metabolite and intermediate we list for Donepezil.

Donepezil impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Donepezil EP Impurity F
Catalogue No.	VQ-025372
CAS Number	145546-80-1
IUPAC name	(2E)-2-[(1-benzylpiperidin-4-yl)methylidene]-5,6-dimethoxy-3H-inden-1-one
Molecular formula	C₂₄H₂₇NO₃
Molecular weight	377.5 g/mol
Exact mass	377.1991
Grade	Reference Standard
HSN code	38229090
InChIKey	LPMOTUSFDTTWJL-UDWIEESQSA-N
SMILES	COC1=C(C=C2C(=C1)C/C(=C\C3CCN(CC3)CC4=CC=CC=C4)/C2=O)OC
PubChem CID	10762160

Physical properties
Physical form	Solid
LogP (XLogP3)	4.2
H-bond donors / acceptors	0 / 4
TPSA	38.8 Å²
Synonyms	(2E)-Dehydrodonepezil, Donepezil - Impurity F, Donepezil Related Compound A, (E)-2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxyindan-1-one, 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxyindan-1-one, (E)-, 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one, 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine, (E)-2-((1-benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one, (2E)-2-[(1-benzylpiperidin-4-yl)methylidene]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one, 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methylene]-, (2~{E})-5,6-dimethoxy-2-[[1-(phenylmethyl)piperidin-4-yl]methylidene]-3~{H}-inden-1-one, 2-[(1-Benzyl-4-piperidyl)methylene]-5,6-dimethoxy-1-indanone

Safety & hazard information (GHS)

Toxic

Signal word: Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements: P264, P270, P301 + P316, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Donepezil EP Impurity F?

The CAS Registry Number of Donepezil EP Impurity F is 145546-80-1. It is also known as (2E)-Dehydrodonepezil, Donepezil - Impurity F, Donepezil Related Compound A.

What is the molecular formula and molecular weight of Donepezil EP Impurity F?

Donepezil EP Impurity F has the molecular formula C24H27NO3 and a molecular weight of 377.5 g/mol. Its IUPAC name is (2E)-2-[(1-benzylpiperidin-4-yl)methylidene]-5,6-dimethoxy-3H-inden-1-one.

What is Donepezil EP Impurity F used for?

Donepezil EP Impurity F is supplied as a characterised reference material related to Donepezil. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Donepezil EP Impurity F can I order?

We supply Donepezil EP Impurity F in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Donepezil EP Impurity F?

Yes. Every lot of Donepezil EP Impurity F is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Donepezil EP Impurity F be shipped internationally?

Yes. Donepezil EP Impurity F is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.