Abemaciclib D8

Name: Abemaciclib D8
Brand: Vaqora Chemicals
SKU: VQ-024105

About Abemaciclib D8

Listed under CAS 2088650-53-5, Abemaciclib D8 is a stable isotope labelled analogue related to Abemaciclib available from Vaqora Chemicals. The compound has the formula C27H32F2N8, corresponding to a molecular weight of 514.6 g/mol. It is also known as Abemaciclib-d8 (piperazine-d8).

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Good laboratory practice and suitable PPE are recommended during handling.

This isotope-labelled compound is used as an internal standard for LC-MS and LC-MS/MS quantitation of Abemaciclib and related analytes in bioanalytical, pharmacokinetic and impurity studies. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Abemaciclib D8 in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

LC-MS/MS internal standard
Bioanalytical quantitation
Pharmacokinetic studies

Industries

Related to Abemaciclib

View every impurity, metabolite and intermediate we list for Abemaciclib.

Abemaciclib impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Abemaciclib D8
Catalogue No.	VQ-024105
CAS Number	2088650-53-5
IUPAC name	5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)-N-[5-[(2,2,3,3,5,5,6,6-octadeuterio-4-ethylpiperazin-1-yl)methyl]-2-pyridinyl]pyrimidin-2-amine
Molecular formula	C₂₇H₃₂F₂N₈
Molecular weight	514.6 g/mol
Exact mass	514.322
Grade	Reference Standard
HSN code	38229090
InChIKey	UZWDCWONPYILKI-JNJBWJDISA-N
SMILES	[2H]C1(C(N(C(C(N1CC)([2H])[2H])([2H])[2H])CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F)([2H])[2H])[2H]
PubChem CID	129010154

Physical properties
Physical form	Solid
LogP (XLogP3)	3.8
H-bond donors / acceptors	1 / 9
TPSA	75 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Abemaciclib D8?

The CAS Registry Number of Abemaciclib D8 is 2088650-53-5. It is also known as Abemaciclib-d8 (piperazine-d8).

What is the molecular formula and molecular weight of Abemaciclib D8?

Abemaciclib D8 has the molecular formula C27H32F2N8 and a molecular weight of 514.6 g/mol. Its IUPAC name is 5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)-N-[5-[(2,2,3,3,5,5,6,6-octadeuterio-4-ethylpiperazin-1-yl)methyl]-2-pyridinyl]pyrimidin-2-amine.

What is Abemaciclib D8 used for?

Abemaciclib D8 is supplied as a characterised reference material related to Abemaciclib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Abemaciclib D8 can I order?

We supply Abemaciclib D8 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Abemaciclib D8?

Yes. Every lot of Abemaciclib D8 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Abemaciclib D8 be shipped internationally?

Yes. We export Abemaciclib D8 worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.