Afatinib Bis-dimethylamino Impurity

Name: Afatinib Bis-dimethylamino Impurity
Brand: Vaqora Chemicals
SKU: VQ-035346

About Afatinib Bis-dimethylamino Impurity

Vaqora Chemicals supplies Afatinib Bis-dimethylamino Impurity, an impurity of Afatinib registered under CAS number 2414260-31-2. Formula C26H32ClFN6O3, molecular weight 531.0 g/mol. Its systematic (IUPAC) name is N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-3,4-bis(dimethylamino)butanamide. Common synonyms include Afatinib Impurity 43.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Good laboratory practice and suitable PPE are recommended during handling.

Pharmaceutical QC and development laboratories use this impurity standard of Afatinib to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Afatinib

View every impurity, metabolite and intermediate we list for Afatinib.

Afatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Afatinib Bis-dimethylamino Impurity
Catalogue No.	VQ-035346
CAS Number	2414260-31-2
IUPAC name	N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-3,4-bis(dimethylamino)butanamide
Molecular formula	C₂₆H₃₂ClFN₆O₃
Molecular weight	531 g/mol
Exact mass	530.2208
Grade	Reference Standard
HSN code	38229090
InChIKey	VZAJTMWUJFLJIB-ZVAWYAOSSA-N
SMILES	CN(C)CC(CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4)N(C)C
PubChem CID	154631190

Physical properties
Physical form	Solid
LogP (XLogP3)	3.4
H-bond donors / acceptors	2 / 9
TPSA	91.9 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Afatinib Bis-dimethylamino Impurity?

The CAS Registry Number of Afatinib Bis-dimethylamino Impurity is 2414260-31-2. It is also known as Afatinib Impurity 43.

What is the molecular formula and molecular weight of Afatinib Bis-dimethylamino Impurity?

Afatinib Bis-dimethylamino Impurity has the molecular formula C26H32ClFN6O3 and a molecular weight of 531 g/mol. Its IUPAC name is N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-3,4-bis(dimethylamino)butanamide.

What is Afatinib Bis-dimethylamino Impurity used for?

Afatinib Bis-dimethylamino Impurity is supplied as a characterised reference material related to Afatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Afatinib Bis-dimethylamino Impurity can I order?

We supply Afatinib Bis-dimethylamino Impurity in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Afatinib Bis-dimethylamino Impurity?

Yes. Every lot of Afatinib Bis-dimethylamino Impurity is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Afatinib Bis-dimethylamino Impurity be shipped internationally?

Yes. We export Afatinib Bis-dimethylamino Impurity worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.