Afatinib dimaleate

Name: Afatinib dimaleate
Brand: Vaqora Chemicals
SKU: VQ-021442

About Afatinib dimaleate

Afatinib dimaleate is a high-purity reference standard of Afatinib carrying the CAS registry number 850140-73-7. The compound has the formula C32H33ClFN5O11, corresponding to a molecular weight of 718.1 g/mol. Common synonyms include Afatinib maleate and Afatinib maleate (JAN).

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

As a reference sample of Afatinib, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Afatinib dimaleate is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Afatinib

View every impurity, metabolite and intermediate we list for Afatinib.

Afatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Afatinib dimaleate
Catalogue No.	VQ-021442
CAS Number	850140-73-7
IUPAC name	bis((Z)-but-2-enedioic acid);(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
Molecular formula	C₃₂H₃₃ClFN₅O₁₁
Molecular weight	718.1 g/mol
Exact mass	717.1849
Grade	Reference Standard
HSN code	38229090
InChIKey	USNRYVNRPYXCSP-JUGPPOIOSA-N
SMILES	CN(C/C=C/C(=O)NC1=C(C=C2N=CN=C(C2=C1)NC3=CC(=C(C=C3)F)Cl)O[C@@H]4COCC4)C.C(=C\C(=O)O)\C(=O)O.C(=C\C(=O)O)\C(=O)O
PubChem CID	15606394

Physical properties
Physical form	Solid
H-bond donors / acceptors	6 / 16
TPSA	238 Å²
Synonyms	Afatinib maleate, Afatinib maleate (JAN), Afatinib (BIBW2992) Dimaleate, Afatinib dimaleate (USAN), EX-A065B

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Environmental hazard

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H319Causes serious eye irritation
H361Suspected of damaging fertility or the unborn child
H362May cause harm to breast-fed children
H372Causes damage to organs through prolonged or repeated exposure
H373May causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P203, P260, P263, P264, P264 + P265, P270, P273, P280, P301 + P317, P305 + P351 + P338, P318, P319, P330, P337 + P317, P391, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Afatinib dimaleate?

The CAS Registry Number of Afatinib dimaleate is 850140-73-7. It is also known as Afatinib maleate, Afatinib maleate (JAN), Afatinib (BIBW2992) Dimaleate.

What is the molecular formula and molecular weight of Afatinib dimaleate?

Afatinib dimaleate has the molecular formula C32H33ClFN5O11 and a molecular weight of 718.1 g/mol.

What is Afatinib dimaleate used for?

Afatinib dimaleate is supplied as a characterised reference material related to Afatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Afatinib dimaleate can I order?

We supply Afatinib dimaleate in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Afatinib dimaleate?

Yes. Every lot of Afatinib dimaleate is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Afatinib dimaleate be shipped internationally?

Yes. Afatinib dimaleate is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.